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《Stomatology》 2008-08
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Research on expression of pERK in human periodontal ligament cells under orthodontic mechanical force

CHEN Zai-hong,YAN De-quan,YIN Mei-nv.(Center of Stomatology,Taizhou Hospital,Linhai 317000,Zhejiang Province,China)  
Objective To investigate the correlation between orthodontic mechanical force and the expression of pERK in human periodontal ligament cells.Methods HPDLCs were tested for Vimentin and Ck(pan) by immunocytochemistry.After subjected to cyclic strain force on 1,6,12,24 and 48 h,protein expression of pERK was determined by Western Blot.Results After treatment of the cells,the expression of pERK was higher as time went,and it was significant(P0.01).The expression of pERK protein declined after 12 hours.Conclusion Mechanical stress on ERK can regulate the signal of HPDLCs.As time went,phosphated ERK was changed.
【CateGory Index】: R783.5
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【References】
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1 ZHANG Xiao-dong,SONG Jiu-yu,LI Yong-ming,LIN Zhu.(Department of Stomatology,Shenyang Military General Hospital,Shenyang 110840,China);Effects of cyclic-tension force on expression of collagen-Ⅲ and fibronectin in HPDLF[J];Stomatology;2011-01
【Co-references】
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1 LIU Qing-meiCapital Institute of Physical Education,Beijing 100088,China.;Effects of Sports on p38MAPK[J];Journal of Capital Institute of Physical Education;2007-04
2 CAO Yang1, ZHENG Yi2, CHEN Yang-Xi3, LUO Song-Jiao31Department of Orthodontics,Guanghua College of Stomatology, Sun Yat-sen University, Guangzhou 510055, China, 2Smile Research Center of Stomatology, Zhuhai 519000, China, 3Department of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China;Effects of mechanical strain on expression of ERK1/2 in osteoblastic cells in vitro[J];Journal of the Fourth Military Medical University;2007-18
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【Secondary References】
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1 ZHANG Hai-bo1,WU Jin-peng1,YANG Chun2(1.Institute of Biomedical Engineering,Peking Union Medical College,China Academy of Medical Sciences,Tianjin 300192,China;2.School of Basic Medical Sciences,Southern Medical University);Progress on the research of regulation effect of fibroblasts with acupuncture-moxibustion[J];Chinese Acupuncture & Moxibustion;2012-12
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