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《Stomatology》 2008-08
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Research on expression of pERK in human periodontal ligament cells under orthodontic mechanical force

CHEN Zai-hong,YAN De-quan,YIN Mei-nv.(Center of Stomatology,Taizhou Hospital,Linhai 317000,Zhejiang Province,China)  
Objective To investigate the correlation between orthodontic mechanical force and the expression of pERK in human periodontal ligament cells.Methods HPDLCs were tested for Vimentin and Ck(pan) by immunocytochemistry.After subjected to cyclic strain force on 1,6,12,24 and 48 h,protein expression of pERK was determined by Western Blot.Results After treatment of the cells,the expression of pERK was higher as time went,and it was significant(P0.01).The expression of pERK protein declined after 12 hours.Conclusion Mechanical stress on ERK can regulate the signal of HPDLCs.As time went,phosphated ERK was changed.
【CateGory Index】: R783.5
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【Secondary References】
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1 ZHANG Hai-bo1,WU Jin-peng1,YANG Chun2(1.Institute of Biomedical Engineering,Peking Union Medical College,China Academy of Medical Sciences,Tianjin 300192,China;2.School of Basic Medical Sciences,Southern Medical University);Progress on the research of regulation effect of fibroblasts with acupuncture-moxibustion[J];Chinese Acupuncture & Moxibustion;2012-12
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