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《Journal of Comprehensive Stomatology》 2005-04
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Experimental Study of Tea Polyphenols on T-Lymphocytes of Recurrent Aphthous Ulcer in Rats.

LIANG Wen-hong, LIU Jian-guo, GUO Yu-su,et al. Department of Oral Medicine, Affiliated Stomatological Hospital of Zunyi Medical College, Zunyi 563003  
Objective: To observe the relationship between cellular immune and the pathogenesis of recurrent aphthous ulcer (RAU) and to evaluate the immune regulation of tea polyphenols(TP)on RAU. Methods: RAU models were established by injecting antigens into SD rats. Five groups, including control group, ulcer cataplasm group and three TP therapeutic groups, were divided randomly. The changes of CD_4~+ and CD_8~+ values in blood were measured by flow cytometry (FCM). Results: Compared with normal group, the values of CD_4~+ and CD_4~+/CD_8~+ showed significantly lower level in RAU rats (P0.01), while CD_8~+ not(P0.05). After TP treatment, the values of CD_4~+ and CD_4~+/CD_8~+ increased significantly (P0.05). It did not show any significant difference among three TP therapeutic groups(P0.05). Conclusion: The inhibition of cellular immune function may contribute to RAU incidence; TP had the immune regulation on experimental RAU rats, which wasn't related to the way of administration in this experiment.
【Fund】: 贵州省卫生厅基金资助项目
【CateGory Index】: R285.5
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