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《Journal of Oral Science Research》 2006-02
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Antibacterial Activities of Different Proportions of Ornidazole and Pefloxacin Against Periodontal Pathogen in Vitro.

DUAN Yan-hua,LIU Lu-chuan,JIANG Yan,et al.Department of Stomatology,Daping Hospital & Research Institute of Surgery,the Third Military Medical University,Chongqing 400042  
Objective: To understand antibacterial activities of different proportions of Ornidazole and Pefloxacin against periodontal pathogen in vitro.Methods: 1) Ornidazole and Pefloxacin are divided to six levels,in order to measure the changes of antiblastic indexes of different proportions of Ornidazole and Pefloxacin against Pg,Fn,Pi,and Peptostreptococcus spp.Statistical test is used to seek the indistinctive ranges of antibacterial activities of Ornidazole and Pefloxacin against those four kinds of typical periodontal pathogens,and to find the suitable proportion.2) To measure MIC and MIC50 of Ornidazole and Pefloxacin and the most suitable proportion against all bacterias.Results: The ranges of indistinctive antibacterial activities for four kinds of typical periodontal pathogens are 6∶1~1∶2,6∶1~2∶3,6∶1~2∶3 and 6∶1~1∶1. Conclusion: The proportion of 2∶3 can inhibit anaerobic bacterium and aerobic bacteria effectively,however,animal experiment and clinical verification are needed.
【Key Words】: Ornidazole Pefloxacin Antibacterial activities
【CateGory Index】: R781.4
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