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《Science Technology and Engineering》 2008-05
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Observation of the Biological Performance of the Spherical β-TCP Bioceramic

MA Chao,WANG Zhen,LU Jian-xi1,Lü Rong,CHEN Guo-jing, LU Bin,YUAN Wei(Department of Orthopaedics,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,P.R.China;Shanghai Bio-Lu Biomaterials Co.Ltd1,Shanghai 200018,P.R.China)  
To explore the biological performance of the spherical porous β-TCP bioceramic implanted in vivo,spherical porous β-TCP bioceramics(the spherical diameter was 2 cm,the pore size was(500~600) μm,the pore interconnection size was(110~120) μm were harvested at 1,2,4,8 and 12 weeks after implanted into muscle-fascia lumbodorsalis pouches in New Zealand rabbits,to observe the biological performances by means of histological and scan electronic microscopic(SEM) analyses.No inflammatory reaction was found in biomaterials.1 week post-operately,cells penetrated into pores.Collagen fibers and immature vessel buds on the 2nd week and the numbers of them increased highly in 4 weeks were found.Crescent-shaped neo-bones and osteoids appeared in the peripheral areas of pores in 8 weeks.In 12 weeks mature vasculatues and bones,and the degradation of materials as well were deteded.Spherical porous β-TCP bioceramic demonstrated a good biological performance of cell penetration,vascularization and osteogenesis.The process of osteogenesis in the bioceramic is membrane bone formation and the extent of vascularization is restricted by the interconnection between pores.
【Fund】: 上海市科委重大项目(05DJ14005)资助
【CateGory Index】: R318.08
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