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Desertliving cistanche anti-aging action:A comparative study

XU Hui,WEI Xiao-dong,OU Qin,LI Ying,XU Xiao-xia,WANG Jing-tao,TIAN Guo-zhong(Jiamusi University,Jiamusi 154007,China)  
Objective:To investigate the age-related changes in anti-oxidation of rat liver mitochondria induced by D-gal and the anti-aging effects of desertliving cistanche and its water extract,ethanol solution and polysaccharide components at the level of mitochondria.Methods:We used the aging rat induced by D-gal as research sample.We measured the Ca2+-ATPase activity in rat liver and determined the MDA content,membrane fluidity and PLA2 activity in rat liver mitochondria in an attempt to study the effects of different components of desertliving cistanche on the above-mentioned indexes.Results:The MDA content and PLA2 activity were markedly decreased,and the Ca2+-ATPase activity and membrane fluidity were obviously increased by giving the water extract,ethanol solution and polysaccharide components to the desertliving cistanche groups(P0.05,P0.01).In the water extract group,the water extract was able to cause the above indexes up to the level of the young group but the effects of ethanol solution and polysaccharide components were relatively inferior.Conclusion:Desertliving cistanche different components can postpone aging by raising the liver anti-oxidation function,reducing the damage by the peroxidation of the liver mitochondria,with the effect of desertliving cistanche water extract better than that of other components.
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