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《The Journal of clinical Pediatrics》 2003-04
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A clinical analyses of102patients with childhood lead poisoning in Shanghai

Yan Chonghuai,Shen Xiaoming,Xue Minbo,Yu Xiaogang,Jin Xingming,Zhang Yanping,Markowitz M.Xinhua Hospiˉtal,Shanghai Children's Medical Center affiliated to Shanghai Second Medical University,Shanghai Institute for Pediatric Research,Shanghai200092  
The purpose of these analyses was to assess the common symptoms of lead poisoning,high_risk factors of lead exposure,medical histories,and to characterize the diagnosis and treatment of the children with lead poisoning at clinics in Shanghai.The authors collected and analyzed the clinical data which was from patients at the lead clinics in both Xinhua Hospital and Shanghai Children's Medical Center during last half year.102patients were diagnosed with lead poisoning.In these patients,the geometrical mean blood lead level was129μg/L.Most of the patients had symptoms of hyperactivity,attention deficits in classroom,and poor academic achievement in school.Some patients had abdominal pain,constipation,anemia and low levels of serum zinc.Most patients had high_risk factors of lead exposure,such as hand washing was infreˉquent before meals,calcium intake was lower than the50%of DRI,hand_mouth activity was common(nail biting)and these were substantial histories of passive smoking exposure from cigarettes.The blood lead level(BLL)decreased significantly(geometrical mean from148μg/L drop to117μg/L)of39patients who were followed in the clinic prospectively,and guidance education were provided relating to high_risk factors,enviˉronmental intervention and behavior correct,and nutrition guidance.One of the patients with BLL of784μg/L was chelated with two medications,DMSA and EDTA_Na 2 _ Ca,in the hospital.The child may need additional courses of chelation in the future.
【Fund】: 国家自然科学基金资助 (项目编号30070665)
【CateGory Index】: R725.9
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