Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical Pediatrics》 2007-08
Add to Favorite Get Latest Update

Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in children with Kawasaki disease

SHEN Jie,LI Jin-kang,HUANG Min,HUA Yang-de,YANG Xiao-dong,CHEN Xiu-yu,LIU Jia-ying(Department of Cardiology,Shanghai Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China)  
Objective To investigate the serum levels of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)for the evaluation of their roles in the pathogenesis of Kawasaki disease(KD).Methods Serum levels of MMP-9 and TIMP-1 were detected by ELISA in 33 patients with KD(six cases associated with coronary artery lesion(CAL)),10 febrile patients with infection and 10 afebrile children without infection enrolled as control,respectively.Peripheral neutrophil and C reactive protein(CRP)were determined simultaneously in three groups.Results The serum levels of MMP-9 and TIMP-1 were significantly higher in the patients with KD than those in either febrile or afebrile groups.Serum level of MMP-9 in patients with CAL was higher than that in cases without CAL,while no diffe-rence in the level of TIMP-1 was observed between patients with or without CAL.After treatment of IVGG plus Aspirin,serum level of MMP-9 decreased to normal range and TIMP-1 level maintained slightly higher in the patients with KD.The increase of MMP-9 correlated positively with the increase of peripheral neutrophil and CRP.Serum TIMP-1 level was higher in the KD patients either with CAL or without CAL.There was no significant difference in the ratio of MMP-9/TIMP-1 between KD group and control groups.The ratio of MMP-9/TIMP-1 after treatment in the KD group was lower than that in the afebrile group,and without difference with the febrile group.Conclusions MMP-9 is involved in the pathophysiological process of KD as a damage factor that could be inhibited by TIMP-1.The serum levels of MMP-9 may reflect the seve-rity of KD,such as KD associated with CAL.
【CateGory Index】: R725.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 LIU Gui-ying1,ZHANG Xiao-hong2,SUN Jing-hui2,SU Ying1,XU Ji-min1(1.Department of Pediatrics,Anzhen Hospital,Capital University of Medical Sciences,Beijing 100029,China;2.Department of Pediatrics,First Hospital,Jilin University,Changchun 130021,Jilin,China);Clinical significance of anti-β2 glycoprotein 1 antibody and matrix metalloproteinase-9 and their association with Kawasaki disease[J];Journal of Clinical Pediatrics;2009-11
2 DU Jun-bao,YAN Hui;Clinical research progress in childhood cardiovascular diseases[J];Chinese Journal of Practical Pediatrics;2008-05
Chinese Journal Full-text Database 2 Hits
1 YANG Shi-wei, WANG Da-wei, LI Jun, QIN Yu-ming, WANG Feng-ming, CAO Li-ming, ZHANG Lan-fang, HU Zheng. Department Cardiovascular Medicine, Nanjing Children′s Hospital, Nanjing Medical University, Nanjing 210008, China;Matrix metalloproteinase-1 expression in the circulation of patients with Kawasaki disease and its role in the pathogenesis of coronary artery lesions[J];Chinese Journal of Pediatrics;2005-08
2 PENG Qian, ZHOU Tong-fu, CHEN Chang-hui, HUA Yi-min, LIU Han-min, HONG Hua, ZHANG Ling-ying, WU Qing.Department of Pediatrics, The People′s Hospital of Sichuan Province, Chengdu 610072, China;Clinical value of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 for the prediction and early diagnosis of coronary artery lesion in patients with Kawasaki disease[J];Chinese Journal of Pediatrics;2005-09
Chinese Journal Full-text Database 6 Hits
1 LI Xiao-lin,ZOU Zheng,ZOU Da-wei(The Children's Hospital of Jiangxi Province,Jiangxi Nanchang 330006,China);Glucocorticoid and Kawasaki Disease[J];Journal of Pediatric Pharmacy;2009-04
2 YANG Shi-wei,WANG Da-wei,QIN Yu-ming,CAO Li-ming,LI Jun(Department of Cardiology,Nanjing Children′s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China);Effects of All-Trans Retinoic Acid on Matrix Metalloproteinase-9 and Tissue Inhibitor of Matris Metalloproteinase-1 Expressions in Peripheral Blood Mononuclear Cells from Acute Kawasaki Disease Children[J];Journal of Applied Clinical Pediatrics;2006-21
3 HUANG Pei(Department of Pediatrics,People′s Hospital of Jurong City,Jurong 212400,China);Significance of Expression of Matrix Metalloproteinase 1 in Peripheral Blood of Children with Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2007-21
4 HE Yue′e,XIANG Ru-lian,ZHANG Yuan-hai,CHEN Qi.(Department of Pediatric Cardiovascular Diseases,Affiliated Children′s Hospital,Wenzhou Medical College,Wenzhou 325000,China);Research Study about Pathogenesis of Kawasaki Disease[J];Medical Recapitulate;2007-14
5 YANG Nan.(Department of Cardiology,Tianjin Children's Hospital,Tianjin 300074,China);Kawasaki Disease and Vascular Endothelial Dysfunction[J];Medical Recapitulate;2009-04
6 BAI Feng-zhi,YANG Shao-juan,WU Xiao-dong,et al.(China-Japan Union hospital of Jilin Univeristry,Changchun 130033,China);Matrix metalloproteinase-1 and Matrix metalloproteinase-9 expression in the peripheral blood of children with Kawasaki disease accompanied by coronary artery lesions[J];Chinese Journal of Laboratory Diagnosis;2008-04
Chinese Journal Full-text Database 10 Hits
1 LIU Gui-ying,ZHANG Xiao-hong,DU Jun-bao,et al(Pediatrics Department,Beijing Anzhen Hospital,Beijing 100029);The level and clinical value of anti-beta 2-glycoprotein 1 antibodies in the plasma of children with Kawasaki diseases[J];Beijing Medical Journal;2007-10
2 JIN Hong-fang1, DU Shu-xu1, ZHAO Xia1, ZHANG Su-qing1, TIAN Yue1, BU Ding-fang2, TANG Chao-shu3,4△, DU Jun-bao1,4△(Peking University First Hospital 1. Department of Pediatrics, 2. Centre Laboratory, 3. Institute of Cardiovascular Research, Beijing 100034, China; 4. Key Laboratory of Molecular Cardiovascular Diseases, Ministry of Education, Beijing 100083, China);Significance of endogenous sulfur dioxide in the regulation of cardiovascular system[J];Journal of Peking University(Health Sciences);2007-04
3 YAN Hui1, MI Jie2, LIU Ying1, CHENG Hong2,JIN Hong-fang1, CHEN Jian-jun1, ZHANG Xiu-zhi1, TANG Chao-shu3, DU Jun-bao1 (1.Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; 2. Department of Epidemiology, Capital Institute of Pediatrics; 3. Institute of Physiology and Pathophysiology, Peking University Health Science Center);Screening for dyslipidemia based on family history combined with obesity in children[J];Journal of Peking University(Health Sciences);2007-06
4 DING Ya-guang1,QI Jian-guang1*,TANG Chao-shu2,3,DU Jun-bao1,3 *(1.Department of Pediatrics;2.Institute of Cardiovascular Research,the First Hospital of Peking University;3.Key Laboratoryof Molecular Cardiovascular Diseases,Ministry of Education of China,Beijing 100034,China);Effect of adrenomedullin on proadrenomedullin N-terminal 20-peptide and hypoxic pulmonary vascular structural remodeling in rats[J];Basic & Clinical Medicine;2007-01
5 HUANG Min, SHEN Jie, CHEN Xiu-yu, CHEN Shu-bao, HUANG Mei-rong, HUANG Guo-ying, HONG Jian-guo, GUO Zhong-zhen, ZHOU Xiao-xun ( Department of Cardiology, Shanghai Children' s Hospital, Shanghai Jiaotong University, Shanghai 200040, China; Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; Department of Cardiology, Children's Hospital of Fudan University, Shanghai 200032, China; Department of Pediatrics, Shanghai First People' s Hospital of Jiaotong University, Shanghai 200080, China; Department of Pediatrics, Shanghai Sixth People' s Hospital of Jiaotong University, Shanghai 200023, China; Department of Pediatrics, Tongji Hospital of Tongji University, Shanghai 200063, China);Clinical manifestations of 50 children with fulminant myocarditis in Shanghai[J];Journal of Clinical Pediatrics;2007-02
6 SUN Xiao-jie,LIU Han-min,WANG Xiao-qin,WANG Juan,YU Li(Department of Pediatrics, The Second West China Hospital Affiliated to Sichuan University,Chengdu 610041,Sichuan,China);Effects of endogenous carbon monoxide on gene expression profiles associated with the proliferation of pulmonary arterial smooth muscle cells[J];Journal of Clinical Pediatrics;2007-04
7 XI Li,GUI Yong-hao,SHENG Feng,XU Su-mei(Cardiovascular Center,Pediatric Hospital Affiliated to Fudan University,Shanghai 200032,China);Use of Harada score in the prediction of coronary arterial lesions in Kawasaki disease[J];Journal of Clinical Pediatrics;2007-04
8 YANG Si-rui,SUN Jing-hui,LI Yang,HAN Yan-yan,ZHOU Yan,LIU Shi-cheng(Department of Pediatric Cardiology,First Hospital Affiliated to Jilin University,Changchun 130021,Jilin,China);Clinical characteristics and treatment of 87 children with supraventricular tachycardia[J];Journal of Clinical Pediatrics;2007-05
9 LI Yun1,HE Xue-hua2(1.Cardiology Department,Shanghai Children's Medical Center Affiliated Shanghai Jiaotong Universiy School of Medicine,Shanghai 200127,China;2.Pediatric Department,Hunan Provincial People's Hospital,Changsha 410000,Hunan,China);Diagnosis and treatment of pulmonary artery sling[J];Journal of Clinical Pediatrics;2007-06
10 QIU Zhong-yan1,WANG Yu-chuan1,LIU Jun-shi2,ZHEN Liu-bo2,ZHANG Quan-jiang1,TAO Jing1,WU Yue1,ZHOU Yan-ming1(1.Department of Pediatrics,People's Hospital of Guizhou Province,Guiyang 550002,Guizhou,China;2.Cardiovascular Disease Hospital of Guizhou Province,Guiyang 550002,Guizhou,China);Relationship between body mass index and blood pressure in adolescent and children[J];Journal of Clinical Pediatrics;2007-07
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved