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《Journal of Clinical Pediatrics》 2008-04
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Urinary tract infection and vesicoureteric reflux

XU Hong (Department of Nephrology and Rheumatology,The Children's Hospital Affiliated to Fudan University,Shanghai 200032,China)  
Urinary tract infection(UTI)is a common bacterial infection disease in young children. Approximately 1.8% of boys and 6.6% of girls will have suffered at least one episode of UTI by age 6 years. The relationship between urinary tract infection,vesicoureteric reflux and reflux nephropathy is complex and controversial. There is no doubt that UTI is the most potent cause of renal scarring,if VUR co-exists. The most commonly used imaging examinations for children with UTI include renal ultrasound,micturating cystogram and DMSA scan. DMSA scan is now regarded as the gold standard for detecting renal scarring. It is recommended that all children with UTI(especially 2 years old=should undergo some of imaging examination,such as ultrasound,VCUG,and DMSA, although the protocols may vary depending on a number of factors including age and sex of child and clinical circumstances. Further,the inheritance of VUR is well recognized:the prevalence of VUR in siblings is much higher than in general population. The natural history of VUR is of spontaneous resolution over time,and surgical correction is,therefore,not necessary in most cases. Prophylactic antibiotics in low dose are generally given to children with VUR under the age of 5 years. Long-term complications of reflux nephropathy are development of end-stage renal failure in later life.
【CateGory Index】: R726.9
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