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《Journal of Clinical Otorhinolaryngology》 2004-07
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Intratympanic dexamethasone injections for intractable Meniere's disease

LU Yongde REN Jihao WU Weijing YIN Tuanfang YANG Xinming XIE Dinghua (Department of Otorhinolaryngology, the Second Hospital of Xiangya Medical College,Central South University,Changsha, 410011,China)  
Objective:To investigate the efficacy of intratympanic dexamethasone injections (IDI) for 15 patients with intractable Meniere's disease (MD). Method:Dexamethasone ( 2.5 mg/ 0.5 ml) was injected into the middle ear and followed by a second injection 15 minutes later. The injection was repeated the next day and weekly for 3 weeks. Total dose of dexamethason was 17.5 mg.Result:The 15 patients were followed up for 18 months (average). Complete relief of vertigo was maintained in 10 cases, improved in 2 case, injection wos repeatad 3 patients with recurrent vertigo resulted in control of vertigo.Tinnitus disappeared in 5 cases, reduced in 5 cases, unchanged in 5 cases. Hearing was improved in 10 cases, unchanged in 5 cases.Conclusion:IDI is effective for intractable MD. The benefits of IDI are avoidance of systemic use of steroids, lower cost, easy application. IDI can be used as an initial surgical treatment for persistent vertigo in MD and indicated for bilateral MD.
【CateGory Index】: R764.33
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