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《Journal of Clinical Otorhinolaryngology》 2006-16
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Intratympanic dexamethasone medication for suddensen sorineural hearing loss: clinical evaluation

SHI Jun YANG Jun WU Hao XUE Bin CHEN XiangpingCAO Rongping MENG Guozhen XIANG Mingliang HUANG Qi(Department of Otolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China)  
Objective:To investigate clinical efficacy of intratympanic dexamethasone injection for sudden sensorineural hearing loss.Method:Subjects received an course of at least 7-day dexamethasone [5 g/(L·d)] intratympanic injection.Pure-tone averages(PTA) calculated using air conduction thresholds at 4-frequencies(500,(1 000),2 000,4 000 Hz) at pre-injection and post-injection were compared.The change in PTA greater than 10 dB HL was considered to be effective.Result:PTA at pre-injection and post-injection were(65.65±24.73)dB HL and(50.25±25.59)dB HL respectively in 21 patients with sudden sensorineural hearing loss.There was significant improvement in PTA(P0.01).Improvement in hearing was found in 47.6% patients.Promising results of intratympanic dexamethasone medication were found in cases with shorter duration or/and without vertigo.No unexpected adverse events such as otitis media or perforated tympanic membrane or worsening in hearing occurred during the injection or follow-up period.Conclusion:Intratympanic dexamethasone medication can be beneficial in treating patient with sudden sensorineural hearing loss.Duration and vertigo are two important factors for prognosis.
【Fund】: 上海市科委资助课题(No:034119819)
【CateGory Index】: R764.43
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【References】
Chinese Journal Full-text Database 2 Hits
1 Deng Cuiping,Lin Haiyan,Ou Yongkan;Nursing for patients with sudden deafness treated by Jiaqiangnong drum injection under ear endoscope[J];Journal of Nurses Training;2008-15
2 JIA Daijie QIN Zhaobing LU Wei LI Sujuan CHEN Xiaohua(Department of Otorhinolaryngology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China);Intratympanic dexamethasone for refractory sudden deafness[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-07
【Citations】
Chinese Journal Full-text Database 2 Hits
1 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
2 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Shao Jun,Guo Guang-wei,Su Ji-ping(Department of Otolaryngology and Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Methylprednisolone of Intratympanic Injection for Refractory Sudden Sensorineural Hearing Loss[J];Guangxi Medical Journal;2009-06
2 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
3 REN Jihao LU Yongde YIN Tuanfang LIU Bin GE Yilin (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone injections for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-05
4 SUN Xialing REN Jihao LU Yongde YIN TuanfangWU Weijing TANG Yueying HU Binya(Department of Otolaryngology,the Second Hospital of Xiangya Medical College,Central South University,Changsha, 410011,China );Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2007-04
5 PENG Yikun XIONG Shizheng CHENG Yonghua QI Yifei YANG Yang(Department of Otolaryngology, Guizhou Province People′s Hospital, Guiyang, 55002,China);Clinical investigation of different routes of administration of dexamethasone on sudden deafness[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-10
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HUANG Zeng-ping*, LI Hao. *Department of Anesthesiology, Shenzhen Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen 518033, China;Therapeutic effects of middle cervical sympathetic ganglion block on sensorineural hearing loss and tinnitus[J];Chinese Journal of Neuromedicine;2005-08
2 WANG Chang Hai 1, WANG Wen 1, LI Jun Chang 1, WANG Zong Ren 1, FENG Wen 1, MA Shi Ping 1, WANG Hong Cai 2 1Department of Traditional Chinese Medicine, XiJing Hospital, Fourth Military Medical University, Xian 710033, China, 2Chinses Traditional Chinese Medicine Research Institute Acupuncture and Moxibustion Institut, Beijing 100700, China;Effects of acupuncture on nailfold microcirculation in patients with sudden deafness[J];Journal of The Fourth Military Medical University;2003-05
3 yang daoshunNo. 54,Bashan Road,Huanggu District,Shenyang Liaonig Province,China;Research of Acupuncture Treatment of Acoustic Nerve Cytometaplasia Deafness[J];Gansu Journal of Traditional Chinese Medicine;1994-04
4 WANG He-yu, GE Hai (The Third People's Hospital of Qingdao,Shandong Qingdao 266041,China);The effects comparison of buflomedi hydrochloride and lidocaine in patients with sudden deafness[J];Hebei Medicine;2003-10
5 XIAO Yufang, WEN Jianqing (Department of Nursing Care, Gaozhou People’s Hospital, Gaozhou 525200, China);Implementation of Humanity Star-level Nursing Care[J];Journal of Nursing Science;2004-05
6 Cheng Kai (College of Acupuncture and Moxibustion, Beijing University of Traditional Chinese Medicine Beijing 100029);Research on the Specificity of the Effects on Auditory Brainstem Responses of Puncturing Different Acupoints on the Small Intestine Meridian of Hand-Taiyang[J];Journal of Beijing University of Traditional Chinese Medicine;2003-02
7 XU Ya ping 1 ZHOU Jun fu 2 XING Chang quan 1 ( 1 Department of Otorhinolaryngology,the Second Hospital of Zhejiang Medical University,Hangzhou 310009; 2Cardio cerebro Vascular Disease Institute,the Second Hospital of Zhejiang Medical Univer;Study on stepwise regression of risk factors in patients with sudden deafness[J];JOURNAL OF CLINICAL OTORHINOLARYNGOLOGY;2000-01
8 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
9 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
10 LU Yongde REN Jihao WU Weijing YIN Tuanfang TANG Yueying XIE Dinghua (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone for sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LIN Yunjuan,YU Lisheng (Department of Otolaryngology,People's Hospital, Peking University,Beijing,100044,China);Determination of the dexamethasone in the cochlear tissue after postaurical and intramuscular injection[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2009-07
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 SU Jiping 1 Bachmann G 2 TANG Anzhou 1 Zumegen C 2 Michel O 2 Wittekindt C 2 ( 1Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021; 2Klinik und Poliklinik für Hals , Nasen , Ohrenheilkunde, der Universitt zu Kln);The different levels of prednisolone in perilymph after local and systemic treatment[J];Journal of Clinical Otorhinolaryngology;2003-10
2 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
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