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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2008-06
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The expression and significance of hypoxia inducible factor-1α and microvessed density in human nasopharyngeal carcinoma

SUI Jun WU Jinpeng LI Xiaojiang MA Jing CAO Xiaojuan GAO Wei REN Yanxin(Department of Head and Neck Surgery,the Third Affiliated Hospital of Kunming Medical College,Kunming,650118,China)  
Objective:To examine the expression of HIF-1α and CD34 in nasopharyngeal carcinoma and nasopharyngitis tissues,evaluate the role of HIF-1α and microvessel density(MVD)in nasopharyngeal carcinoma,probe the relationship between HIF-1α and MVD.Method:The expression of HIF-1α was detected in 58 cases with nasopharyngeal carcinoma and 20 samples of nasopharyngitis tissues by immunohistochemical staining SABC methods and SP methods.MVD in tumor was counted by immunostaining with CD34 and analyzed with clinicopathologic parameters.Result:The positive rate of HIF-1α was 79.31% and 10.00% respectively in nasopharyngeal carcinoma and nasopharyngitis tissues,there was significant difference between them(P0.01).MVD was 39.74±7.41 and 18.43±3.24 respectively in nasopharyngeal carcinoma and nasopharyngitis tissues,there was significant difference between them(P0.01).The expression of HIF-1α and MVD were significantly higher in nasopharyngeal carcinoma and in lymph node metastasis group than in no-metastasis group.In different clinical stage,the expression of HIF-1α(P0.05)and MVD(P0.01)was different.The expression of HIF-1α was positively correlated with MVD(P0.01).Conclusion:HIF-1α may be involved in carcinogenesis,invasion and metastasis of NPC.Visualization plays a key role in invasion and metastasis of NPC.The expression of HIF-1α was positively correlated with tumor visualization in NPC.HIF-1α is likely to be a potential target of anticancer therapy.
【Fund】: 云南省教育厅科学研究基金(No:06z129c)
【CateGory Index】: R739.63
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