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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2008-10
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Clinical investigation of different routes of administration of dexamethasone on sudden deafness

PENG Yikun XIONG Shizheng CHENG Yonghua QI Yifei YANG Yang(Department of Otolaryngology, Guizhou Province People′s Hospital, Guiyang, 55002,China)  
Objective:To investigate the therapeutic effects of conventional treatment with different routes of administration of dexamethasone on sudden deafness.Method:Eighty-four patients with sudden deafness were included in this prospective randomized study. Twenty one patients(group 1)were treated with taking dexamethasone orally combined with conventional methods. Another 21 patients (group 2) were treated with intravenous dexamethasone injection combined with conventional methods. Group 3 (21 patients) were treated with intratympanic dexamethasone injection by the way of external ear combined with conventional methods. The other 21 patients (group 4) were treated with intratympanic dexamethasone injection by the way of pharyngotympanic tube combined with conventional methods. The hearing gains at 0.5, 1.0, 2.0, 4.0 kHz and the mean values were compared among four groups.Result:The average hearing gains of 1, 2, 3 and 4 group was 21.3 dB, 27.5 dB, 43.2 dB and 48.1 dB respectively. Group 3 and group 4 had statistical difference compared with group 1 and group 2 in the average hearing gains. There was no obviously statistical difference between group 1 and group 2 and between group 3 and group 4. In patients with PTA≤70 dB, the average hearing gains at 0.5, 1.0, 2.0, 4.0 kHz had no obvious difference (P0.05) among four groups. However, in patients with PTA70 dB, there was statistical difference between group 1, 2 and group 3, 4 (P0.05), the hearing gains of group 3, 4 were apparently higher than that of group 1, 2. However, there was no significant difference of hearing gains between group 1 and group 2 (P0.05) and between group 3 and group 4 (P0.05).Conclusion:The conventional drug treatment with taking dexamethasone orally or intravenous dexamethasone injection had no obvious effect on sudden deafness with PTA70 dB, but the conventional drug treatment with intratympanic dexamethasone injection is a useful treatment for sudden deafness. Comparison with whole body administration, intratympanic dexamethasone injection is more convenient to use in clinic, and with less prohibitions and complications. Patients with PTA70 dB should take intratympanic dexamethasone injection in early days.
【CateGory Index】: R764.43
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
2 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
3 PENG Yikun YANG Yang JIANG Ya CHEN Xiaoling YU Xiaosong (Department of Otorhinolaryngology,Guizhou Province People′s Hospital,Guiyang,550002,China);To investigate the relation of sudden deafness with hearing loss level and auditory threshold[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2007-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIN Xian Qing (Department of Otolaryngology, Leqing Second Peoples Hospital, Leqing 326508);Curative effect survey of compound root of red rooted salvia injection liquid treating sudden deafness[J];Anhui Medical and Pharmaceutical Journal;2001-03
2 Fu Xipin,Yang Wenjun Zhuji City TCM Hospital,Zhejiang Province(311800);TCM Acupuncture and Moxibustion Treat Sudden Deafness[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-05
3 CHEN Li-tao,LUO Wen-long,GAN Xiu-ni,et al.(Department of Otolaryngology,Head and Neck Surgery,Second Affilicaled Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China);Related study on psychiatric interfere to sudden deafness[J];Chongqing Medicine;2006-02
4 ZHANG Fan,JIANG Yuan-shi.Shantou Central Hospital,Shantou 515031,China;Relationship between sudden deafness and cavernous space cerebral infarction in cerebral cortical fundi[J];Chinese Journal of CT and MRI;2004-03
5 WANG Shu-hui,REN Ji-hao,LU Yong-de,et al. Department of Otorhinolaryngology, The Second Xiangya Hospital, Central South University,Changsha 410011, China;Detection of Plasma Endothelins and Serum Nitric Oxide in the Patients with Sudden Sensorineural Hearing Loss[J];Journal of Chinese Physician;2005-04
6 WANG Jin-Ling; HUANG Wei--Guo; GUO Meng He; ZHANG Shu; YUAN Jun;(Department of Otorhinolaryngology, Xijing Hospital. Fourth Military Medical University, Xi'an710033 China,) HUANG Shi-Rong; LIU Yan--Hong(Department of Otorhinolaryngology,Railway Building;The treatment of sudden deafness with the combination of large doses snake venom antithrombus enzyme and vasodilator[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-01
7 ;Study on the nourishing kidney and eliminating stasis to resusitation in treating sudden deafness[J];Research of Otorinolaryngology of Traditional Chinese Medicine;2006-02
8 XIAO Yuli,ZHANG Lei,YAN Jie (Department of Otolaryngology Head and Neck Surgery,Affiliated the Second Hospital of Harbin Medi-cal University,Haerbin,Heilongjiang,150086, China);The clinical study of dexamethasone in treatment of sudden hearing loss and the influence on nitric oxide and glutathione peroxidase[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2006-02
9 Kui Xixiao Department of Otolaryngology,Guangdong Province Yuebei People's Hospital,Shaoguan 512026Xie Changhui,Li Shuwu,Liu Xuguang,Xiong Qibing;Clinical value of regional cerebral blood flow SPECT for sudden sensorineural deafness[J];;1999-01
10 YAN Hua,DUAN Hua-lin,ZHANG Hui-jia,YU Pei-jun,HU Ji-hong,DING Xiang.(Rehabilitation Center of Hunan Children′s Hospital,Changsha,Hunan 410007,China);Clinical effect of the audio frequeney resonance treatment on the children with brain impair syndrome accompanied with nervous deafness.[J];Chinese Journal of Child Health Care;2009-01
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 WANG Mingshan1 WANG Xiaoxia1 CHEN Xiaodong1 CHEN Jianfu2 (1Department of Laboratory Medicine,First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000; 2Department of Otolaryngology,First Affiliated Hospital of Wenzhou Medical College);Study on the coagulation state of sudden deafness[J];JOURNAL OF CLINICAL OTORHINOLARYNGOLOGY;2000-07
2 SU Jiping 1 Bachmann G 2 TANG Anzhou 1 Zumegen C 2 Michel O 2 Wittekindt C 2 ( 1Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021; 2Klinik und Poliklinik für Hals , Nasen , Ohrenheilkunde, der Universitt zu Kln);The different levels of prednisolone in perilymph after local and systemic treatment[J];Journal of Clinical Otorhinolaryngology;2003-10
3 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
4 LU Yongde REN Jihao WU Weijing YIN Tuanfang TANG Yueying XIE Dinghua (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone for sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-01
5 REN Jihao LU Yongde YIN Tuanfang LIU Bin GE Yilin (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone injections for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-05
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