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《Journal of Clinical Otorhinolaryngology Head and Neck Surgery》 2009-03
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The expression and relationship of vascular cell adhesion molecule-1 and P-selectin and microvessel density in hypopharyngeal carcinoma

LIANG Dapeng1 PAN Xinliang1 SUN Wenhai2 HUANG Yichuan2 (1Department of Otolaryngology Head and Neck Surgery,Qilu Hospital of Shandong University,Jinan,250012,China;2Department of Otolaryngology Head and Neck Surgery,the Affiliated Hospital of Medical College,Qingdao University)  
Objective:To investigate the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) and P-selectin in hypopharyngeal carcinoma,and explore the relationship of VCAM-1,P-selectin and microvessel density (MVD).Method:Expression of VCAM-1 and P-selectin were detected by immunohistochemistry staining in 40 specimens of hypopharyngeal carcinoma and 10 specimens of normal mucosa of oral pharynx. MVD was assessed based on the expression of CD34.Result:VCAM-1 and P-selectin were detected in 26 out of 40 (65%) and 29 out of 40 (72.5%) respectively in hypopharyngeal carcinoma,but none that in normal mucosa(P0.01). MVD in hypopharyngeal carcinoma was higher than that in normal mucosa and it was related to lymph node metastasis. MVD level was significantly higher in VCAM-1 and P-selectin-positive specimens than in negative ones(P0.01),which also positively correlated with the expression of VCAM-1 and P-selectin(P0.01). The expression of P-selectin positively correlated with VCAM-1 in hypopharyngeal carcinoma specimens with lymph node metastasis.Conclusion:The higher expression of VCAM-1 and P-selectin play key roles in the invasion and metastasis of hypopharyngeal carcinoma and were correlated with vascularization.
【CateGory Index】: R739.65
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