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Relationship between serum high sensitivity C-reactive protein and intima-media thickness of carotid artery in subjects with type 2 diabetes

LV Xiao-hong~*,SU Sheng-ou,WANG Jie-chao,KANG Su-xian,YUE Yuan,SONG Xiao~*Department of Internal Medicine,the Elders′ Diseases Hospital of Hebei Province,Shijiazhuang 050011,China  
Objective To investigate the relationship of serum high sensitivity C-reactive protein(hsCRP) to intima-media thickness(IMT) of the carotid artery in subjects with type 2 diabetes mellitus(T2DM).Methods Serum hsCRP level was measured by immunonephelometric assay and IMT of the carotid artery was determined by high-resolution ultrosonography in 62 diabetic and 30 normal subjects.According to the hsCRP level,the diabetic patients were divided into two subgroups: low hsCRP group(0.05-3 mg/L,30 cases) and high hsCRP group(3-10 mg/L,32 cases).After a year's comprehensive therapy,hsCRP and IMT of the carotid artery were examined again in the patients with T2DM.Results The IMT of carotid artery was significantly increased in high hsCRP group as compared with that in low hsCRP group(1.05±0.15) mm vs(0.84±0.12) mm(P0.05) after a year′s treatment.Both before and after the therapy,serum hsCRP correlated positively with IMT of the carotid artery in the patients of high hsCRP group with T2DM(r=0.882,r=0.905,all P0.05,respectively).Conclusion Elevated serum hsCRP may be one of probable risk factors in the early atherosclerosis in the patients with T2DM.
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