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《Clinical Focus》 2013-12
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Expression and significance of Th17 cytokines in labial salivary glands of patients with primary Sjogren syndrome

YU Zhi-bo;ZHANG Feng-xiao;ZHENG Gui-min;LI Fang;SUN Li-jun;TAO Jie-mei;ZHANG Li-tao;Department of Rheumatology and Immunology, Hebei General Hospital;Department of Emergency, Hebei General Hospital;  
Objective The purpose of this study is to investigate the expression and significance of interleukin17(IL-17),interleukin 6(IL-6)and tumor necrosis factorα(TNF-α)in the labial salivary glands of patients with primary Sjogren syndrome(pSS).Methods The expression of IL-17,IL-6and TNF-α were detected by using immunohistochemistry SP method in 30patients with pSS and 10control subjects,the optical density values were measured in the same paraffin section.Results The average optical density of IL-17,IL-6,TNF-αin pSS group revealed significantly higher values in comparison to those in control group,respectively 0.078±0.012vs 0.210±0.077;0.079±0.014vs 0.245±0.083;0.081±0.007vs 0.251±0.073(P 0.01).In 30pSS cases,there were 5gradeⅠ,7gradeⅡ,12gradeⅢand 6gradeⅣ,according to the degree of lymphocyte infiltration classification.The positive expression of IL-17inⅠ,Ⅱ,Ⅲ,Ⅳ grade were 0.094±0.029,0.171±0.052,0.240±0.030,0.293±0.050,respectively,the positive expression of IL-6,0.120±0.066,0.244±0.070,0.281±0.064,0.278±0.050,the positive expression of TNF-α0.138±0.049,0.241±0.067,0.283±0.046,0.290±0.043.Through variance analysis,the expression of IL-17,IL-6,TNF-αhad statistic significance between different grades(P 0.05).There were positive correlation between positive expression of IL-17,IL-6and TNF-αand the grades of lymphocyte infiltration(r=0.814,0.469,0.591,all P 0.01).Conclusion IL-17,IL-6and TNF-αparticipated in the local inflammatory reaction of labial salivary glands in pSS patients.There are correlation between the expression of three cytokines and lymphocyte infiltration.Th17cytokines may play an important role in the pathogenesis of pSS.
【Fund】: 河北省医学科学研究重点课题(20090241)
【CateGory Index】: R593.2
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