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《Journal of Clinical Pulmonary Medicine》 2015-11
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Analysis of the correlation between CD_4~+CD_(25)~+ regulatory T cells in peripheral blood and blood glucose in pulmonary tuberculosis patients complicated with diabetes mellitus

YIN Xiao-fang;GE Hai-bo;MA Jian-hua;SUN Si-qing;Department of Tuberculosis,Nanjng Chest Hospital;  
Objective To investigate the correlation between CD_4~+CD_(25)~+regulatory T cells in peripheral blood and blood glucose in pulmonary tuberculosis patients complicated with diabetes mellitus. Methods The study selected 40 PT patients complicated with diabetes mellitus as the group A,38 patients with active pulmonary tuberculosis as the group B,35 patients with diabetes mellitus as the group C and 30 healthy people as the control group. The percentages of CD_4~+CD_(25)~+Treg cells in peripheral blood,fasting blood glucose( FBG),two hours postprandial blood glucose( 2h PBG) and glycosylated hemoglobin( Hb A1c) were detected. Then the correlation between CD_4~+CD_(25)~+regulatory T cells and blood glucose was analyzed. Results The percentage of CD_4~+CD_(25)~+Treg cells in peripheral blood was the highest in group A( t = 2. 71,2. 41,3. 23 respectively,P 0. 05). CD_4~+CD_(25)~+Treg cells in peripheral blood had no significantly liner correlation with FBG or 2h PBG in the group A( P 0. 05),while it showed a positive linear correlation with Hb A1c( r = 0. 293,P = 0. 014). Conclusion The percentage of CD_4~+CD_(25)~+Treg cells in peripheral blood increases in active tuberculosis patients complicated with diabetes patients,and it has a positive linear correlation with Hb A1 c,which plays a role in the development of the disease.
【Fund】: 南京市医学科技发展项目(No YKK13093)
【CateGory Index】: R587.1;R521
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