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《JOURNAL OF CLINICAL RADILOLGY》 1998-06
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Soap Bubble" Sign-An Uncommon X-ray Sign of Bone in Patients with Hodgkin Lymphoma

Huang Yao; Shi Mulan; Wang Xuelei. (Cancer Hospital, ChineseAcademy of Medical Sciences, PUMC, Beijing 100021)  
Objective: An unusual "soap bubble" sign of bone in 9 patients with Hodgkin lymphoma (HD) were reviewed, in order to improve the knowledge of X-ray differential diagnosis. Materials and Methods: From 1959 to 1995, there were 32 HD patients with bone involvement, 9 patients (28. 12% ), had "soap bubble" sign. The age ranged from 14 to 65 years old. The subtypes of HD were nodular sclerosis in 5 cases, mixed cellular in 3 cases, lymphocytic predominance in 1 case. Bone lesions were solitary in 8 cases and multiple in 1 case. All had X-ray films of bone. Results: Lesions were found in sternum and iliac bone for 3 cases each, rib in 2 cases and radius in 1 case, with well-defined margins. 4 cases had total or partial sclerotic rim, 9 cases had intalesional coarse or fine trabecullae, and 1 case had lacy-like peirosteal reactions. 5 cases had local soft tissue mass. After treatment, tumor decreased in size was found in 5 cases, thickening of sclerotic rim in 3 cases, thickening of intralesional trabecullae in 6 cases. Conclusion: "Soap bubble" sign of HD of bone might have some relationship with the histologic subtype. HD of bone should be included in the differential diagnosis consideration with "soap bubble" sign.
【CateGory Index】: R733.1
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wane Bin, Zhang Yonghong, Yang Jing, Jin Ling. Beijing Children′s Hospital Affiliated Capital Medical University, Beijing 100045, China;Hodgkin's lymphoma with osseous lesion in children with 3 case report[J];Journal of China Pediatric Blood and Cancer;2006-04
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 WU Qiqiu;CHENG Hong;LIN Yu, et al Beijing Tuberculosis & Chest Tumor Hospital, Department of Orthopedics, Beijing 101149, China P. R.;Spinal malignant lymphoma:Report of 18 cases[J];Chinese Journal of Bone Tumor and Bone Disease;2003-05
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