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《Journal of Clinical Radilolgy》 2002-02
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Correlation of Dynamic CT Indices with VEGF Expression in Brain Astrocytoma

ZHANG Dong, XU Weibang, ZOU Liguang,et al. Department of Radiology, The Affiliated Xinqiao Hospital, No.3 Military Medical University, Chongqing 400037, P.R.China  
Objective To study the correlation of dynamic CT indices with VEGF expression in brain astrocytoma.Materials and Methods Dynamic CT scanning was performed in 38 patients with surgically and pathologically proved astrocytoma. Based on time density curve, the indices, including TBRP, TBRL, ascending slope of time density curve (S) and the area under the time density curve were calculated. VEGF within the tumor cells of the specimen was dyed with immunohistochemical method. VEGF expression was measured and compared with the dynamic CT indices.Results VEGF expression in astrocytoma was well correlated with the pathological grade and clinical prognosis. Significant difference in TBRP, TBRL, S and area existed between grade Ⅲ~Ⅳ and grade Ⅰ~Ⅱ (P0.05). TBRP, TBRL, S and area showed a positive correlation with VEGF expression (P0.05).Conclusion The extent and pattern of enhancement in astrocytoma on dynamic CT scan have a close correlation with VEGF expression. It is workable to evaluate VEGF expression of astrocytoma with dynamic CT scanning.
【CateGory Index】: R739.4
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