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《Journal of Clinical Radiology》 2008-11
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The DSA and CT Perfusion Evaluation of New Model of Artery Occlusion in Monkey

ZHOU Zhipeng,DENG Yanxian, QIU Weijia,et al.Department of Radiology,Affiliated Hospital of Guilin Medical College 541001,P.R.China  
Objective To investigate the role of DSA and CT perfusion (CTP) scanning in monkey middle cerebral artery occlusion (MCAo) model, which were established by various doses of fibrin embolus injected into the middle cerebral artery(MCA). Materials and Methods 20 monkeys were randomly assigned to 5 groups including control, mild ischemia, moderate ischemia, serious and very serious ischemia groups.The various doses of embolus lodge were injected from the segment M1 of MCA in monkey and characterized their effects on cerebral blood flow by DSA and neurological deficit was observed in 14 days.CT perfusion was performed at 30 mins and 120 mins after operation to measure MTT values. Results The MTT values were significantly higher in operation groups than that in control group at 30 mins after operation, there was no significant difference between mild ischemia and control group, there was significant difference between moderate, serious, very serious and control group, MTT values in serious, very serious groups were higher than that in other groups, MTT values in very serious group were higher than that in serious group. Neurological deficit was observed in mild, moderate and serious ischemia groups. Conclusion Establishment of an embolic monkey model of stroke is important to study cerebral ischemia disease, DSA and CTP are helpful for early diagnosis and prognosis of cerebral ischemia disease.
【CateGory Index】: R743.3
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