Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Hepatology》 2006-04
Add to Favorite Get Latest Update

The levels of TGFβ1, IL-12, IFNγand other cytokines in patients with primary hepatic carcinoma and their clinical significances

KONG Li, YAO Shu -kun, ZHANG Rui -xing, et al. (Department of Liver Diseases, the Third Hospital of Hebei Medical University, He Bei, Shijiazhuang, 050051 , China )  
To investigate the levels of serum TGf-β1 , IL - 2, IL - 12, TNFαand IFNγin patients with primary hepatic carcinoma (PHC). 50 cases of PHC were enrolled to this study. Compared with controls, TGF -β1 , TNF -αlevel were significantly increased (P = 0. 014, P = 0. 0001) and the levels of IFNγ, IL - 2 and IL - 12 were significantly decreased in patients with PHC ( P = 0. 008 , P = 0. 018 , P = 0. 007). TGF -β1 was negatively correlated with TNF -α(r= - 0. 350, P0. 05) and IL-2 (r= -0.476, P0. 01), IL - 12 was positively correlated with IFN -γ( r = 0. 612, P0. 01), TBil (r=0.439, P 0. 01 ) . In II b and III stage of PHC, the concentration of TGF -β1 and TNF -αwere higher than that in I and II a stage ( P 0. 05 , P 0. 05 ) , and the concentration of IFNγ, IL - 2 and IL - 12 were lower than that in I and II a stage (P 0. 05 , P 0. 05 , P 0. 05). These data showed that cytokines levels were disordered in PHC patients , and the network of cytokines were imbalance, and anti - tumor immune function were inhibited, especially in medium - later period. It might be one of the causative factors of the tumor progress.
【CateGory Index】: R735.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 CHU Guang-ping,ZHU Qi-yi(Department of Hepatobiliary Surgery,the Fifth Affiliated Hospital of Guangxi Medical University,Liuzhou 545001,China);Study Progress about Genetics of Malignant Hepatobiliary Tumor[J];Medical Recapitulate;2007-19
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Liuan Health School,Anhui 237005HAN Chun;The progress of T lymphocyte subgroup systematization and immunologic function[J];Journal of Anhui Health Vocational & Technical College;2003-03
2 HUANG Jin ling, LONG Zi jiang, WU Hua qiang, WANG Tong sheng, FANG Yi ying (Anhui Collge of Traditional Chinese Medicine, Anhui Hefei 230038, China);Effect of Linggui Zhugan Decoction on Lymphocyte Activities in Immunosuppressed Mice Induced by Cyclophosphamide[J];Journal of Anhui Traditional Chinese Medical College;2004-01
3 ZHANG Wan-gao,LEI Jin-sheng,ZHANG Yu-mei(Department of Interventional Radiology,Huainan Mining Industry 4th Miner's Hospital,Huainan 232000,China);Metal stent combined with arterial intubation chemotherapy for advanced esophageal carcinoma[J];Journal of Bengbu Medical College;2006-03
4 LI Wei-peng,ZHENG Zuo-ya,WANG Hong,WANG Cong-zhu,HANG Qin,ZHAO Wei-guo(Shanghai Municipal Research Center of Medical Laboratory Science,Medicine College of Shanghai Jiaotong University,Shanghai 200023,China);Cloning,construction and purification of recombinant human B-type natriuretic peptide[J];Journal of Bengbu Medical College;2007-01
5 LI Hong-zhao, YAN Yan-hua (Department of Immunology, Tianjin Medical University, Tianjin 300070, China);The Effect of Human Chorionic Gonadotropin on the Activity of NK Cell[J];Labeled Immunoassays and Clinical Medicine;2001-03
6 WANG Wei, YE Yi-xiu, YAN Guang-tao, et al. (The 309th Hospital of PLA, Beijing 100091, China);Evaluation and Measurement of IL-8 in Patients with Severe Acute Respiratory Syndrome[J];Labeled Immunoassays and Clinical Medicine;2004-01
7 GAO Hang 1, WANG Jian wei 1, ZHANG Hai ying 1, WANG Lin 1, QIAN Cheng 2, CHEN Li 1, CHEN Yuan yao 1 (1. Dept. of Pathology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China;2. Navarra University, Spain);Inhibitory Effect of Adenovirus Vector Carrying Murine GM-CSF Gene on B16 Melanoma[J];Journal of Jilin University of (Medicine Edition);2003-06
8 ZHAO Ke-wei (School of Sports & Health,East China Normal University,Shanghai 200062,China);A Summary of the Research Progress in the Effects of Exercise on Interleukin-l,Interleukin-2 and Interleukin-6[J];Journal of Beijing Teachers College of Physical Education;2005-05
9 JI Wen feng,JIAO Deng guo,HOU Jian, et al.ChangZheng Hospitol,The Second Military Medical University,(Shanghai,200003) [;TUMOR LYSIS SYNDROME:11 CASE REPORT[J];Journal of Leukemia & Lymphoma;2003-04
10 KH2D][WT5BZ]DENG Shu hua,et al [WT5BX](Department of Micrology and Immunology,Chengde Medical College, Hebei Chengde 067000,China);SUBSTITUING SPLENIC CELLS OF MICE FORHUMAN LYMPHOCYTES IN THE ROSETTE ASSAY FOR EXPERIMENTAL TEACHING[J];Journal of Chengde Medical College;2000-03
China Proceedings of conference Full-text Database 1 Hits
1 HE Xue-bin,XUE Cun-kuan,CHEN Yan-wen,XU Ming-wang CHEN kai,JIANG Peng,LI Ying,ZHEN Ling (Hu Bei Sheng Geriatric Medical Institute,Wuhan 430077,China);The effect of RNA of barm of beer on Immune Activity of Mice[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 PENG Juan1,2, DING Tong1,3, ZHENG Li-Ming1,3, SHAO Jian-Yong1,21. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China2. Department of Pathology, Cancer Center, Sun Yat-sen University,Guangzhou, Guangdong, 510060, P. R. China3. Department of Biochemistry, School of Life Science, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Influence of Tumor-associated Macrophages on Progression and Prognosis of Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2006-11
2 QIN Dong-Chun1,2, WANG Hai-Ying3, MEI Yuan-Ding1, ZHANG Qin-Xian21Department of Clinical Laboratory, First Affiliated Hospital, 2Basic Medical College, Zhengzhou University, Zhengzhou 450052, China, 3Department of Clinical Laboratory, Henan Hospital of Traditional Chinese Medicine, Zhengzhou 450000, China;Change of immunological functions in patients with primary hepatocellular carcinoma[J];Journal of the Fourth Military Medical University;2007-20
3 LU Wei 1 , LI Yan-hao 1 , HE Xiao-feng 1 , CHEN Yong 1 , ZENG Qing-le 1 , QIU Yu-rong 2 Departments of Interventional Radiology 1 and Clinical Laboratory 2, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Effect of dosage of anticancer agents during transcatheter arterial chemoembolization on T cell subsets in patients with hepatocellular carcinoma[J];Journal of First Military Medical University;2002-06
4 DING Lei,CHEN Xiao-ping,ZHANG Zhi-wei,et al.Hepatic surgery center Affiliated Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China;STUDY ON EXPRESSION OF TOPOISOMERASE Ⅱα IN PRIMARY HEPATOCARCINOMA TISSUES AND ITS RELATIONSHIP WITH p53 GENE MUTATION[J];Journal of Hepatobiliary Surgery;2006-03
5 CHEN Gang, LUO Dian-zhong, LI Ping, et al. Department of Pathology, Guangxi Medical University, Nanning 530021;Immunohistochemical study of natural killer cells in hepatocellular carcinoma and cirrhosis[J];Journal of Hepatopancreatobiliary Surgery;2005-02
6 Fa-Bo Qiu, Li-Qun Wu,Yun Lu, Shun Zhang and Bing-Yuan Zhang Department of Hepatobiliary Vascular Surgery, Affiliated Hospital, Qingdao University Medical College, Qingdao 266003, China;Predominant expression of Th1-type cytokines in primary hepatic cancer and adjacent liver tissues[J];国际肝胆胰疾病杂志(英文版);2007-01
7 ZHI Hui,LUO Bao-ming~*,WEN Yan-ling,YANG Hai-yun,OU Bing,MA Jian-hong(Department of Ultrasound in Medicine,the Second Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510120,China);Comparative study on treatment of small hepatocellular carcinoma by radiofrequency ablation and percutaneous ethanol injection[J];Chinese Journal of Interventional Imaging and Therapy;2006-04
8 ZHENG Mu-bai,WANG Jun-ling,LI Xiu-ying,PAN Quan,CAO Ai-mei(Dezhou Peoples Hospital in Shandong Province,Dezhou 253014,China);Study of regional cell immune response on ultrasound guided superantigen injection with anhydrous ethanol injection therapy for hepatocellular carcinoma[J];Chinese Journal of Interventional Imaging and Therapy;2007-03
9 Qiu Dapeng Qiu Shuangjian Wu Zhiquan, et al. (Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032);Investigation of the Distribution and Local Immunology of NKT Cells within Hepatic Cancer Tissue[J];Clinical Medical Journal of China;2004-04
10 QIU Fa-bo,JIANG Xi-hong,WU Li-qun,LU Yun,FENG Jin-bo,ZHANG Jian Department of General Surgery,Qilu Hospital of Shandong University (Jinan 250012,China);The expression of Th1/Th2 type cytokines in primary hepa-tic cancer tissue and its adjacent liver tissue[J];Chinese Journal of Current Advances in General Surgery;2003-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved