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《Chinese Journal of Clinical Hepatology》 2006-04
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The levels of TGFβ1, IL-12, IFNγand other cytokines in patients with primary hepatic carcinoma and their clinical significances

KONG Li, YAO Shu -kun, ZHANG Rui -xing, et al. (Department of Liver Diseases, the Third Hospital of Hebei Medical University, He Bei, Shijiazhuang, 050051 , China )  
To investigate the levels of serum TGf-β1 , IL - 2, IL - 12, TNFαand IFNγin patients with primary hepatic carcinoma (PHC). 50 cases of PHC were enrolled to this study. Compared with controls, TGF -β1 , TNF -αlevel were significantly increased (P = 0. 014, P = 0. 0001) and the levels of IFNγ, IL - 2 and IL - 12 were significantly decreased in patients with PHC ( P = 0. 008 , P = 0. 018 , P = 0. 007). TGF -β1 was negatively correlated with TNF -α(r= - 0. 350, P0. 05) and IL-2 (r= -0.476, P0. 01), IL - 12 was positively correlated with IFN -γ( r = 0. 612, P0. 01), TBil (r=0.439, P 0. 01 ) . In II b and III stage of PHC, the concentration of TGF -β1 and TNF -αwere higher than that in I and II a stage ( P 0. 05 , P 0. 05 ) , and the concentration of IFNγ, IL - 2 and IL - 12 were lower than that in I and II a stage (P 0. 05 , P 0. 05 , P 0. 05). These data showed that cytokines levels were disordered in PHC patients , and the network of cytokines were imbalance, and anti - tumor immune function were inhibited, especially in medium - later period. It might be one of the causative factors of the tumor progress.
【CateGory Index】: R735.7
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