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《Chinese Journal of Clinical Hepatology》 2008-01
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Influences of Protopanaxdiol to vascular endothelial growth factor and basofibroblast growth factor protein expression of liver

LENG Ji-yan,FU Jun,WANG Ji-ping(First hospital,Jilin University,Jilin,Changchun,130021)  
Objective To discuss influences of Protopanaxdiol to vascular endothelial growth factor and basofibroblast growth factor protein expression of liver.Methods To construct liver cancer animal models and the expermental animals are divided into five groups.Each group includes ten animals.That is control group,CTX group,Protopanaxdiol 25mg/kg,50mg/kg,100mg/kg groups.After two weeks,all the expertimental animals will be killed.We'll determine tumor volume and weight,then deal it into tissue spices for immunohistochemistry.Results In Protoanaxdiol groups,bFGF and VEGF protein expression is lower than that control group,its tumor volume and weight is lower distinguishly.Conclusion It suggests that Ppd inhibites expression of VEGF and bFGF protein,finally inhibites tumor growth.
【Fund】: 长春市科技局资助项目(2004072)
【CateGory Index】: R735.7
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