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《Journal of Clinical Orthopedics》 2004-03
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The expression and its clinical significance of CD44v6 in osteosarcoma

You Murong, Liu Xiaoping, Yu Xiuchun, Du Xiumin (Dept of Orthopaedics, the People's Hospital of Tongling, Tongling, Anhui 244000)  
Objective To explore the expression of CD44v6 protein in osteosarcoma and study the relationship between the expression of CD44v6 protein and clinical behavior of osteosarcoma. Methods The expression of CD44v6 protein was detected by Flow Cytometry in the paraffin-embedded tissues from 40 cases of osteosarcoma, 10 cases of giant cell tumor of bone, and 10 cases of osteochondroma tissues were examined as control. The expression of CD44v6 in patients with osteosarcoma and their effects on tumor recurrence, metastasis and prognostic significance were studied. Results The positive expression rate of CD44v6 in osteosarcoma was significantly higher than that in giant cell tumor of bone and osteochondroma. There was no significant correlation between the CD44v6 positive rates and clinicopathological features such as age, sex, locations of lesion and prognosis. The high level expression of CD44v6 in osteosarcoma tissues was associated with its Enneking staging. CD44v6 positive rates in staging≥ⅡB were much higher than that in stagingⅡB(P0.05). Osteosarcoma recurrence showed significantly higher positive rates than non-recurrence(P0.05). CD44v6 in metastasis were significantly higher than that in non-metastasis(P0.05). Conclusion CD44v6 may act as an indicator in the grade of malignancy of osteosarcoma. It is also an adjuvant index in the diagnosis of osteosarcoma. Overexpression of CD44v6 might be an indication for predicting the possibility of recurrence metastasis of osteosarcoma.
【CateGory Index】: R738.1
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