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Study on Anti-tumor Activity of Poplar Bud Extract in vitro

ZHENG Guang-yao1,KANG Hong-xing2,BO Cai-ying1,SONG Qiang1,ZHOU Wei-chun1(1.Institute of Chemistry and Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization;Key and Open Lab.on Forest Chemical Engineering,SFA,Nanjing 210042,China;2.Nanjing Laoshan Forest Farm,Nanjing 211811,China)  
The growth-inhibition effect of poplar bud extract on MCF-7,SMMC-7721 and A549 cell lines by MTT assay were observed and the anti-tumor activity was compared with propolis and poplar gum from market.The results showed that the inhibitory rates of poplar bud extract on the three cell lines for 48h,were 97.1%,88.7% and 60.5%,with the IC50 of 58.4,83.9 and 196.3mg/L,respectively,which were higher than those of propolis and poplar gum.Poplar bud extract has significantly inhibited the growth in vitro on the three cell lines,suggesting that poplar bud extract has obvious anti-tumor activity.
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