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《Journal of Clinical Psychological Medicine》 2004-04
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Association study of serotonin transporter gene polymorphism and depression

WANG Xiao-xiang,MIAO Jing-shen,WANG Shao-hua.The Fourth People's Hospital of Yanchen City,Jiangsu 224003  
Objective:To explore the association between depression and polymorphism of serotonin transporter (5-HTT) and its influence on the antidepressant response. Method:Using a polymerase chain reaction-based technique,polymorphism of 5-HTT-linked polymorphic region (5-HTTLPR) in serotonin transporter gene was determined in 51 patients with depression and 60 control subjects,the allelic and genotypic distributions in two groups were compared.Cases and controls were matched for ethnic and geographic origin.The patients were treated with venlafaxine and measured with Hamilton depression scale (HAMD). Results:The frequencies of 5-HTT short/short (S/S) genotype and allele S were significantly higher in depression patients than in controls(71% vs. 45%;81% vs.69%).The scores of long/long(L/L) genotype patients were significantly lower respectively than those of other genotypes. Conclusion:The findings support that the presence of 5-HTTLPR allele S may increase the risk for depression and that the L allele is associated with better SSRIs response.
【CateGory Index】: R749.4
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