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《Chinese Journal of Clinical Laboratory Science》 2007-06
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Clinical significance of diversity of serum LAP during pregnancy

ZHANG Kui,WEI HongXia,WANG Zhiqun,QIU Fang,WANG Li,GU Guangyu,LUO Xunyang(1.The Department of Medical Laboratory,2.The Department of Gynaecology and Obstetrics,Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China)  
Objective To explain the physiological properties of serum leucine aminopeptidase (LAP) and discuss the different levels and clinical meaning of serum LAP during the second and the third trimester of gestation.Methods Rate turbidimetry was used to assay serum LAP activity of 175 pregnant women in the second trimester of gestation, among whom 162 were normal and 13 were intrahepatic cholestasis of pregnancy (ICP), and 302 pregnant women in the third trimester of gestation, among whom 215 were normal, 76 were ICP, 6 were pregnancy-induced hypertension syndrome and 5 were premature delivery, and 100 healthy or non-pregnant women.Results Serum LAP activity of pregnant women in the group of the second trimester of gestation was (140.43±64.39) U/L, in the group of the third trimester of the gestation was (234.72±93.53) U/L, and in control group was (72.62±15.31) U/L. The serum LAP activities of the two pregnant groups were much higher than that of control group (P0.05). The activity of serum LAP in the pregnant women with ICP was much higher than that of group of normal pregnancy.Conclusion Serum LAP activity stepped up gradually with the increase of gestational weeks.When pregnant women got ICP,their serum LAP activity increased obviously, but LAP activity just increased slightly in the women accompanying hypertension syndrome of pregnancy. In the women with premature delivery LAP activity decreased.Consequently, LAP can be regarded as an auxiliary marker for monitoring the condition of mother and fetus dynamically.
【CateGory Index】: R446.1
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