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《Chinese Journal of Clinical Laboratory Science》 2009-03
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Polymorphism of killer-cell immunoglobulin-like receptor gene family in Han blood donors in Jiangsu

HE Cheng-tao1,LI Li1,2,ZHANG Jian-qiong3,et al.(1.Department of Laboratory Medicine,Clinical Medical College of Southeast University,Nanjing 210009;2.Department of Immunology Laboratory,Zhongda Hospital,Southeast University,Nanjing 210009;3.Key Laboratory of Developmental Genes and Human Diseases,Ministry of Education,Nanjing 210009,Jiangsu,China)  
Objective To investigate the genomic diversity,genotypes,and haplotypes of killer-cell immunoglobulin-like receptor(KIR) in Han population in Jiangsu.Methods DNA samples from 163 voluntary blood donors in Han population in Jiangsu were genotyped with PCR-SSP method.Results(1) Twelve KIR genes,including 1D,2DL1-3,2DL5,2DS1-5,3DL1,3DS1,were observed.All the individuals contained 2DL1 and 2DL3.The most common genes were 3DL1 and 2DS4,followed by 1D,2DL5,2DS1,3DS1,and 2DS5.The rare ones were 2DS2,2DL2,and 2DS3.(2)There were 17 KIR genotypes in the 163 DNA samples;the most frequent types were AJ(2,2) and AF(1,2),followed by AH(5,2) and AG(1,1).Three genotypes(New1,New11,and New19) have not been observed in Caucasians so far,and New19 has not been observed in other populations in China.(3)There were 9 haplotypes in the 163 individuals;the most frequent one was type 2,followed by type 1.Conclusions There are distinctive frequencies of KIR gene contents,haplotypes,and genotypes in Chinese Han population in Jiangsu.The data demonstrate the presence of new KIR genotypes and haplotypes.
【Fund】: 江苏省科技厅社会发展基金资助项目(BS2006542);; 江苏省卫生厅科学技术资助项目(H200757);; 国家大学生创新性实验计划资助项目(G2007058)
【CateGory Index】: R392
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 SU Pincan1,YANG Tonghan2,ZOU Hai3,et al.1.Institute of Blood Transfusion,Chinese Academy of Medical Sciences,Chengdu 610081,China;2.Yunan Kunming Blood Center;3.Sichuan Umbilical Cord Blood Bank;Polymorphism of killer cell immunoglobulin-like receptors gene in Yunnan Han population,China[J];Chinese Journal of Blood Transfusion;2008-04
2 LI Changying,HU Bin,WANG Tongxian,et al.Qingdao Blood Center,Qingdao 266071,China;The distribution of killer immunoglobulin-like receptor genes in Qingdao Han population[J];Chinese Journal of Blood Transfusion;2008-07
3 YIN Xiao-lin1, GUO Kun-yuan1, MA Hong-jing1, SHANG Zheng-chuan1, XIAO Lu-lu2, YE Xin2, ZHAO Yang21Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; 2Guangzhou Tissue Typing Center, Guangzhou 510095, China;Killer immunoglobulin-like receptor gene distribution in Guangdong Han population[J];Journal of First Military Medical University;2004-12
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 SU Pincan1,YANG Tonghan2,ZOU Hai3,et al.1.Institute of Blood Transfusion,Chinese Academy of Medical Sciences,Chengdu 610081,China;2.Yunan Kunming Blood Center;3.Sichuan Umbilical Cord Blood Bank;Polymorphism of killer cell immunoglobulin-like receptors gene in Yunnan Han population,China[J];Chinese Journal of Blood Transfusion;2008-04
2 LI Changying,HU Bin,WANG Tongxian,et al.Qingdao Blood Center,Qingdao 266071,China;The distribution of killer immunoglobulin-like receptor genes in Qingdao Han population[J];Chinese Journal of Blood Transfusion;2008-07
3 XU Ling-di,LU Yu,ZHANG Lei,YANG Jue-qin,YAO Fang-juan,FAN Li-an,Shanghai Institute of Immunology,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China;Association of killer cell immunoglobulin like receptor (KIR) gene polymorphism with Behcet's disease[J];Chinese Journal of Rheumatology;2006-03
4 YIN Xiao-lin, DENG Lan, GUO Kun-yuan, ZHANG Xing-hua (Department of Hematology, The 303rd Hospital of PLA, Nanning 530021, China);Expression of KIR-HLA in Guangdong Han patients with hematologic malignancy[J];Immunological Journal;2006-05
5 FU Shaojie,XIAO Lulu,YU Lixin,LUO Min,ZHU Wei,GUO Wei,WANG Gui,LI Weimo Department of Organ Transplantation,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;The frequencies and polymorphism of KIRs gene on the surface of NK cells in uremia patients[J];Immunological Journal;2009-03
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Wei1,TANG Rongcai2,WANG Chengya3 1.Chongqion Blood Center,Chongqing 400015,China;2.Jiangsu Blood Center;3.The First Affiliated Hospital of Nanjing Medical University;The polymorphism and haplotype analysis of HLA-A,B and DRB1 gene of 20248 donors in CMDP Jiangsu Branch[J];Chinese Journal of Blood Transfusion;2007-04
2 YIN Xiao-lin1, GUO Kun-yuan1, MA Hong-jing1, SHANG Zheng-chuan1, XIAO Lu-lu2, YE Xin2, ZHAO Yang21Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; 2Guangzhou Tissue Typing Center, Guangzhou 510095, China;Killer immunoglobulin-like receptor gene distribution in Guangdong Han population[J];Journal of First Military Medical University;2004-12
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