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《Journal of Clinical Stomatology》 2002-02
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Effects of Salvia Miltiorrhiza Bunge on the Proliferation and Collagen Synthesis in Oral Submucous Fibrosis Buccal Fibroblasts

QUE Guo ying,PENG Jie ying,WU Ying fang,et al.  
Objective To investigate the effects of salvia miltiorrhiza Bunge (SMB) on buccal fibroblasts in vitro.Methods Buccal fibroblasts were cultured and incubated with various concentrations of SMB(30 mg/ml?60 mg/ml?90 mg/ml) solution for 48 h. MTT assay and hydroxyproline reagcuat were used to evaluate the cell proliferation and the collagen production in the culture medium, respectively. Results This study showed that SMB Solution could significantly not only inbibit the growth of the cultured OSF buccal fibroblasts, but also reduce the soluble collagen production in the culture medium in a dose related manner.Conclusion This investigation demonstrated that SMB could significatitly inhibit the proliforation and the collagen synthesis in cultured OSF buccal fibroblasts, and suggested that SMB could play an important role in the treatment of OSF.
【CateGory Index】: R781.5
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