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《Journal of Clinical Stomatology》 2006-04
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Expression and significance of inducible nitric oxide synthase in osseous sarcoma of jaws

FENG Hong-jie,CHENG Wei-liang,LI Jin-song,LI Hai-gan,PAN Chao-bin.Department of Oral-Maxillofacial Surgery,Hangzhou FirstPeople's Hospital,Hangzhou 310006,China  
Objective:To detect expression of iNOS in osseous sarcoma of jaws ,study the relation between iNOS and tumor angiogenesis,also clinicopathological characters.Method:SP immunohistochemistry staining method was applied to detect the expression of iNOS and CD34 in osseous sarcoma of jaws.Result:There is overexpression of iNOS in osseous sarcoma of jaws.Expression of iNOS correlates with microvessel density,also with size,pathological grade,clinical classification of osseous sarcoma of jaws positively,but don't correlates with metastasis of osseous sarcoma of jaws.Conclusion:iNOS could promote tumor angiogenesis in osseous sarcoma of jaws,iNOS may become the molecular target in anti-tumor therapy.
【Fund】: 广东省科技三项经费计划(2005A30801007)
【CateGory Index】: R739.8
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