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《Journal of Clinical Stomatology》 2006-12
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Protective effects of salvia miltiorrhizae injection on vascular endothelial cells damages caused by aqueous areca nut extract

PENG Jie-ying,PANG Dan-lin,QUE Guo-ying,YIN Xiao-min,LI Ming.. Department of Stomatology,Xiangya Hospital,Central South University,Changsha 410008,China  
Objective:To discuss the mechanism of Salvia Miltiorrhizae Injection(SMI)effects on Oral Submucous Fibrosis (OSF) whether through improving the function of the vascular endothelial cell(EC) damaged by aqueous areca nut extract(AANE).Method:EC (from ECV-304) were cultured in vitro and divided into two groups: the protective group and the preventive group. EC were incubated together with SMI before or after EC were influenced by AANE, and we observed the changes of the proliferation of EC and the level of ET-1 secreted by EC.Result:1. The protective group: SMI was incubated together with EC after which were affected by AANE, we found that the number of EC was larger(t=-2.805,P0.05) and the level of ET-1 was lower (t=2.965,P0.05)than those of the contrast. 2. The preventive group: SMI were incubated together with EC before which were affected by AANE, we found that the number of EC(t=2.701,P0.05) and the level of ET-1(t=-1.541,P0.05) were resemble with those of the contrast.Conclusion:Salvia Miltiorrhizae could protect EC through alleviating the injury caused by AANE and play its antifibrotic action by affecting the cells' secreting cytokines.
【Fund】: 湖南省科技厅社会发展基金资助(02SSY3052)
【CateGory Index】: R285.5
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