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《Journal of Clinical Internal Medicine》 2001-01
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Variability of serum,urinary microglobulin and the relationship between serum microglobulin and glomerular filtration rate in diabetics patients

HOU Yingping,DENG Jinglan,ZHANG Zhenming.Department of Nuclear Medicine, Xijing Hospital, the Fourth Military Medical University, Xi an 710032,China  
Objective To observe the variability of serum and urinary β 2 microglobulin(β 2 MG),urinary α 1 microglobulin(α 1 MG) and study the relationship between serum β 2 MG and glomerular filtration rate (GFR) in diabetic patients.Methods The serum β 2 MG,urinary β 2 MG,urinary α 1 MG acquried by radioimmunoassay and GFR acquired by 99 Tc m diethylenetriamine pentaacetic acid ( 99 Tc m DTPA),renal dynamic imaging were measured in 44 diabetics and 20 normal subjects.Results (1)The serum β 2 MG had significantly negative correlation with GFR (P0.01) in diabetics who had lasted less than 1 year or more than 10 years.(2)The level of serum β 2 MG,urinary β 2 MG and urinary α 1 MG in diabetic group was significant higher than that of control group, especially urinary α 1 MG(P0.01).(3)The value of GFR in diabetics lasted less than 1 year was higher than that of control,but inverse in diabetics lasted more than 10 years.Conclusion The level of serum β 2 MG was correlated with GFR to some degree.Urinary α 1 MG might be used as a sensitive marker for early diagnosis of diabetic nephropathy.
【CateGory Index】: R587.1
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