Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical Internal Medicine》 2001-01
Add to Favorite Get Latest Update

Variability of serum,urinary microglobulin and the relationship between serum microglobulin and glomerular filtration rate in diabetics patients

HOU Yingping,DENG Jinglan,ZHANG Zhenming.Department of Nuclear Medicine, Xijing Hospital, the Fourth Military Medical University, Xi an 710032,China  
Objective To observe the variability of serum and urinary β 2 microglobulin(β 2 MG),urinary α 1 microglobulin(α 1 MG) and study the relationship between serum β 2 MG and glomerular filtration rate (GFR) in diabetic patients.Methods The serum β 2 MG,urinary β 2 MG,urinary α 1 MG acquried by radioimmunoassay and GFR acquired by 99 Tc m diethylenetriamine pentaacetic acid ( 99 Tc m DTPA),renal dynamic imaging were measured in 44 diabetics and 20 normal subjects.Results (1)The serum β 2 MG had significantly negative correlation with GFR (P0.01) in diabetics who had lasted less than 1 year or more than 10 years.(2)The level of serum β 2 MG,urinary β 2 MG and urinary α 1 MG in diabetic group was significant higher than that of control group, especially urinary α 1 MG(P0.01).(3)The value of GFR in diabetics lasted less than 1 year was higher than that of control,but inverse in diabetics lasted more than 10 years.Conclusion The level of serum β 2 MG was correlated with GFR to some degree.Urinary α 1 MG might be used as a sensitive marker for early diagnosis of diabetic nephropathy.
【CateGory Index】: R587.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 NING Ping-xia,ZHANG Ya-ping;Analysis on Clinical Value of Examining Urine Microglobulin from Patients with TypeⅡ Diabetes[J];Journal of Henan University of Science & Technology(Medical Science);2008-01
2 LIU Xin-zheng,SUN Li,DONG Jian-xi.Department of Clinical Laboratory,the First Affiliated Hospital of Zhengzhou University,He'nan 450052,China;Clinical Significance of Urinary Micro-Protein in Type 2 Diabetic Patients[J];Applied Journal of General Practice;2008-06
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Li Yi;Li Wenrui;Qiu Wensheng;et al(RUI DONG Diabetes Center of TCM and WM,Beijing Hospital,Beijing 100730);The significance of serum and urinary α_1-microglobuliu in early diagnosis or diabetic nephropathy in NIDDM[J];CHINESE JOURNAL OF DIABETES;1996-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIAO Xiang, LI Jin, ZHANG Qiang, et al.(Teng Zhou Centrol People Hospital, Tengzhou 277500, China);The Application Value of the Ratio Combined Detection of Blood Glucose and GSP and D-3H and Urine β_2-M/Cr in the Patients of Diabetes Mellitus[J];Labeled Immunoassays and Clinical Medicine;2006-02
2 LIAO Pu 1,WANG Shu qing 1,KANG Ge fei 2 (1 Department of Clinical Lab, the Third People's Hospital of Chongqing,400014; 2 Department of Clinical Lab,Chongqing University of Medical Sciences,400016);Relationship between activation of NF-κB and nephropathy in patients with type 2 diabetic mellitus[J];Chongqing Medical Journal;2002-03
3 Li Ying Zhang Yimin Wu Wenqing Li Hong Liu Xiaomei Lan Changsheng Department of Nephrology, the Third Hospital of Hebei Medical University (Shijiazhuang 050051);THE EFFECT OF LOSARTAN ON α_1-MG IN EXPERIMENTAL DIABETIC RATS[J];Journal of Hebei Medical University;2001-04
4 Tang Xiaoming, Huang Cheng * ,Ma Lingjun, Yu Yanni, Zhang Yanli (Department of Biochemistry,Luoyang Medical College *Department of Isotope , Affiliated Hospital of Luoyang Medical College);The importance of α_1 MG,β_2 MG in blood and urine in the early diagnosis of diabetic renopathy[J];;1997-04
5 Kang Jian Department of Anatomy, North Sichuan Medical College, Nanchong 637000 Yang Huijun, Li Aidong Department of Anatomy, School of Basic Medical Sciences, West China University of Medical Sciences, Chengdu 61004;An Observation on Apoptosis and Proliferation of the Renal Tubular Epithelium of rats in the Early Phase of Diabetes Mellitus[J];JOURNAL OF NORTH SICHUAN MEDICAL COLLEGE;1999-02
6 SU Jianbin,WANG Xueqin,CHEN Jinfeng,JIN Yan(Department of Endocrinology,the Second Affiliated Hospital of Nantong University,Jiangsu 226001);Correlation between glomerular filtration rate and multiple risk factors in newly diagnosed type 2 diabetic patients[J];Medical Journal of Communications;2009-04
7 XU Rong juan,LI Hong,TANG Hong, GE Fang fang,ZHAO Dong jieDepartment of Endocrine Diseases, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Experimental Study on“Diabetes Treating and Kidney Protecting Infusion”in Treating Rats with Diabetic Nephropathy of Early Stage[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2000-04
8 WANG Xi-ying,ZHANG Guo-lin;Change and significance of urinary α_1-microglobulin during acute organophosphate insecticide poisoning[J];Chinese Journal of Industrial Medicine;2006-06
9 HOU Zu-qiang, JIANG Xiu-ai, LIU Shu-yun, et al (Department of Clinical Laboratory, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042,China);DETECTION OF SPECIFIC PROTEINS IN SERUM AND URINE IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES MELLITUS[J];Medical Journal of Qilu;2003-04
10 Yan Wanchun.Department of Geriatrics the first hospital of PLA,Lanzhou 730030;Ge Wei.Department of Geriatrics Xijing Hospital of the Fourth Military Medical University,Xi′an 710032;Liang Liquan.Outpatient Department of China Northwest Airlines,Xi′an 710082;Clinical observation of the efficacy of lipo PGE_1 in treating senile diabetic nephropathy[J];Practical Geriatrics;2002-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Danging ,Lin Bin,Li Hua Department of laboralory,Anhui Provincial Hospital,Hefei 230001;Significance of determination of urine microprotein for diagnosing early renal disease in patients with diabetes mellitus[J];Anhui Medical Journal;2001-02
2 LIU Xin-ming reviewing, LIU Xiao-cheng checking (Department of Nephropathy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China);The pathogenic mechanism and therapeutic existing state of diabetic nephropathy[J];Parenteral & Enteral Nutrition;2003-03
3 Wang Qilong, Ma Lei Liangshan People’s Hospital, Liangshan Xiaolukous Hospital, Shandong (272600);Diagnostic Significance of Detection of Micro-Amount of Urinary Proteins for Patients with early Diabetic Nephropathy[J];Journal of Radioimmunology;2005-02
4 ZHOU Yan,MA Jin xiu//The Affiliated Hospital of Guilin Medical Colleg,Guilin 541004,China;Research Progress on Relationship between Diabetic Nephropathy and Insulin Resistance[J];Acta Medicinae Sinica;2003-06
5 Gao Li juan,et al. People's Hospital of Haikou,Hainan Province,Haikou,570001;An Analysis of the Detective Result of Serum β_2-Microglobulin in 87 Aged Patients[J];Hainan Medical Journal;1992-01
6 FU Han-jing, ZHU Liang-xiang, YUAN Shen-yuan, et al . (Department of Diabetes & Endocrinology, Beijing Tongren Hospi tal, Beijing 100005,China);Changes of glomerular filtration rate in different stages of patientswith diabetic nephropathy and its influence factors[J];Basic Medical Sciences and Clinics;2000-06
7 Huang Kaifeng,Jiang Fengxia.The Fifth Hospital of Sun Yat-sen University of Medical Sciences,Zhuhai 519000;The value of determining the β_2-MG content in urine of the patients with breast milk jaundice in early renal damage[J];Chinese General Practice;2003-10
8 (Taian City Central Hospita ,Taian 271000);The Level of Serum β 2-MG in Patients with Malignant Tumor Yufeng, Gaozhengxiu, Dupiuhong et.al.[J];JOURNAL OF QILU ONCOLOGY;1996-04
9 WANG Ying, LUO Xiao-hong, LAO Wei-si, et al. (Laboratory Department, Second Affiliated Hospital of Zhongshan University, Guangzhou 510120, Guangdong, P.R. China);Clinical significance of determination of β_2-microglobulin in patients with multiple myeloma.[J];China Tropical Medicine;2007-02
10 Xu Yujie; Zhang Qingyi; Wu Qingwei (Department of Nophrology, Renji Hospital, Shanghai Second Medical University, Shanghai(200001));Effect of Astragalus Membranaceus on Experimental Diabetic Renal Hypertrophy and Microalbuminuria[J];ACTA UNIVERSITATIS MEDICINALIS SECONDAE SHANGHAI;1997-05
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 LIANG Jing1,KAISAIER·Duolaiti2.1.Department of Clinical Laboratory,Jiangong Hospital of Xinjiang Uygur Autonomous Region,Unumuqi 830002,China;2.Department of Human Anatomy,Preclinical College,Xinjiang Medical University,Unumuqi 830054,China;Relationship between transferring,β_2-microglobulin and microalbminuria in patients with diabetic nephropathy[J];Laboratory Medicine and Clinic;2008-16
2 HUANG Sheng-guang1, TAN Ning2, ZHOU Ru-yun1 (1.Shenzhen Nanshan People's Hospital, Shengzhen 518052, China;2.Hunan College of TCM,Changsha 410007,China);Research on Prevention and Cure of Hyperuricemia with the Chushihuayu Decoction[J];Chinese Journal of Information on TCM;2004-08
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Xiang Kun-san Shanghai Sixth People's Hospital;RENAL HEMODYNAMIC CHANGES BEFORE THE ONSET OF CLINICAL NEPHROPATHY IN NIDDM[J];Chinese Journal of Endocrinology and Metabolism;1990-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved