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《Journal of Clinical Internal Medicine》 2005-03
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Detection and clinical significance of plasma PAF in type 2 diabetic patients with microalbuminuria

YUAN Guoyue,YU Yan,ZHUAN Ruo,et al.RuiJin Hospital affiliated to Shanghai Secondary Medical University, Shanghai Institute of Endocrine And Metabolic Diseases,Shanghai 200025,China  
Objective To observe the level of plasma platelet-activating factor(PAF) and relationship of PAF and urinary albumin excretion rate (UAER) in type 2 diabetic patients with microalbuminuria.Methods The levels of plasma PAF and UAER in 30 healthy subjects (control group),30 type 2 diabetic patients with microalbuminuria and 28 type 2 diabetic patients without albuminuria were measured by bio-assay or radioimmunoassay (RIA).Rusults The levels of plasma PAF and UAER in type 2 diabetic patients without albuminuria were not significantly different as compared with those in control group (P0.05),the level of PAF in type 2 diabetic patients with microalbuminuria was significantly higher than that in group without albuminuria (P0.01) , the level of PAF was positively correlated with that of UAER (r=0.68),especially in microalbuminuric patients (r=0.74).Conclusion An enhanced level of plasma PAF may be involved in the occurrence and development of type 2 diabetic microalbuminuria, the detection of it can be served as a clinical index of the diagnosis、therapy and prognosis of early diabetic nephropathy.
【Fund】: 镇江市科技局社会发展项目SG2001094
【CateGory Index】: R587.1
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