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《Journal of Clinical Internal Medicine》 2019-01
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Therapeutic effect of telmisartan and indapamide on subjects with high-normal blood pressure and abdominal obesity

Su Xiaoli;Wang Xuanqi;Wu Xiaopeng;Zhang Yan;Department of Cardiovascular Medicine,the Fourth People's Hospital of Shaanxi Province;  
Objective To compare the therapeutic effect of telmisartan and indapamide on subjects with high-normal blood pressure and abdominal obesity.Methods A total of 342 subjects with high-normal blood pressure and abdominal obesity were randomly divided into placebo intervention group(group A,88 cases),telmisartan treatment group(group B,123 cases)and indapamide treatment group(group C,131 cases)with 2 years of treatment.Physical indexes,blood pressure,fasting blood glucose(FPG),blood lipid,uric acid(UA),blood potassium levels and ratio of patients with metabolic syndrome(MS)among 3 groups,compliance and treatment costs between group B and C were compared.Results Two subjects discontinued the trial due to abnormally elevated blood pressure and 5 subjects were lost to follow-up in group A.Three subjects withdrew from the trial due to poor compliance and 4 subjects were lost to follow-up in group B.Three subjects withdrew from the trial due to poor compliance and 7 subjects were lost to follow-up in group C.There were 81,116 and 121 subjects in group A,B and C respectively at last.There were significant differences of triglyceride(TG),diastolic blood pressure,UA,blood potassium and ratio of patients with MS between three groups after treatment(P0.05).Waist circumference,body mass index(BMI),blood pressure in three groups,FPG,TG,UA and ratio of patients with MS in group B,TG,blood potassium and ratio of patients with MS in group C after treatment were all lower than those in the same group before treatment,but blood potassium after treatment was higher than that before treatment in group B(P0.05).Blood pressure,TG and ratio of patients with MS in group B and C after treatment were all lower than those in group A.FPG,TG and UA in group B after treatment were all lower than those in group A and C.Blood potassium in group B after treatment was higher than those in group A and C.Blood potassium in group C after treatment was lower than those in group A(P0.05).Treatment cost in group B was significantly higher than that in group C(P0.05),but there was no significant difference of compliance between two groups(P0.05).Conclusion Telmisartan and indapamide can effectively control blood pressure of subjects with high-normal blood pressure and abdominal obesity and telmisartan is more effective.but economic benefit of indapamide is more acceptable.
【CateGory Index】: R544.1
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