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《Journal of Clinical Internal Medicine》 2019-02
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Expression of microRNA-126 and microRNA-155 in patients of coronary heart disease combined with impaired glucose tolerance and intervention of acarbose

Lin Meiping;Wang Jianjun;Internal Medicine,Shandong the Yellow River hospital of the Yellow River River Bureau;  
Objective To explore expression of microRNA(miR)-126 and miR-155 in patients of coronary heart disease(CHD)combined with impaired glucose tolerance(IGT)and intervention of acarbose.Methods A total of 179 patients with CHD(115 patients in simple CHD group,64 patients in CHD combined with IGT group)and 43 healthy volunteers(control group)were concluded.Biochemical indicators and blood glucose related indicators among three groups were compared.qRT-PCR was used to detect the expression levels of plasma miR-126 and miR-155.Patients in simple CHD group were treated with conventional CHD therapy for 3 months.Patients in CHD combined with IGT group were treated with conventional CHD therapy and acarbose tablets for 3 months,and xpression levels of miR-126 and miR-155 in patients of them before and after treatment were detected.Results MiR-126,miR-155,2 h PG,Flns and HOMA-IR among three groups were significantly different(P0.05).MiR-126 and miR-155 levels in simple CHD group were lower than those in control group(P0.05).2 h PG,FIns and HOMA-IR levels in CHD combined with IGT group were higher than those in control group and simple CHD group,miR-126 and miR-155 levels were lower than those in control group and simple CHD group(P0.05).Pearson correlation analysis showed that miR-126 and miR-155 levels were negatively correlated with HOMA-IR and 2 h PG(P0.05).Binary logistic regression analysis showed that HOMA-IR,2 h PG,miR-126 and miR-155 were all associated with CHD combined with IGT(P0.05).MiR-126 and miR-155 levels in patients with CHD combined with IGT group were higher,2 h PG,FIns and HOMA-IR were lower than those before treatment(P0.05).Conclusion Levels of plasma miR-126 and miR-155 in patients of CHD combined with IGT decreased,which may be related with insulin resistance,and acarbose can increase their levels.
【CateGory Index】: R541.4
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