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《Journal of Clinical Internal Medicine》 2019-06
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Relationship between serum microRNA-206 level and pulmonary hypertension in patients with left heart disease

Huang Chunyun;Ni Dianjun;Ni Weijuan;Sun Xia;Department of Cardiology,Renmin Hospital of Longhua district,Shenzhen;  
Objective To investigate the relationship between serum microRNA-206(miR-206)level and pulmonary hypertension(PH)in patients with left heart disease(LHD).Methods A total of 103 LHD patients in our hospital from March 2016 to March 2017 were selected as the study subjects.According to whether combined with PH,they were divided into two groups,LHD combined with PH group(47 cases)and LHD without combined PH group(56 cases).In the same period,50 healthy subjects were selected as control group.Serum miR-206 level was detected by quantificational real-time polymerase chain reaction(qRT-PCR).The correlation among serum miR-206 level and pulmonary hypertension,cardiac function were analyzed.Results There were no significant differences in age,sex,smoking history,diastolic blood pressure(DBP)and heart rate(HR)between the three groups(P0.05),BMI,systolic blood pressure(SBP),New York Heart Association(NYHA)cardiac functional classification,pulmonary artery systolic pressure(PASP),left atriallongitudinal diameter(LAD),left ventricular end-diastolic dimension(LVEDD),right atrial diameter(RAD),left ventricular ejection fraction(LVEF),left ventricularfraction shortening(LVFS)and brain natriuretic peptide(BNP)were statistically significant(P0.05).Compared with healthy control group and LHD without PH group,serum miR-206 level in LHD combined with PH group was significantly lower(P0.05).There was no significant difference in the level of serum miR-206 between LHD without PH group and healthy control group(P0.05).Spearman correlation analysis showed that serum miR-206 level was negatively correlated with PASP and LVEDD(r=-0.512,-0.461,P0.05),and positively correlated with LVEF(r=0.534,P0.05).Univariate analysis showed that there was a significant correlation between NYHA classification,miR-206,BNP,LAD,LVEDD,RAD,RVD and LVEF and PH(P0.05).Logistic regression analysis showed that miR-206,BNP and LAD were independent predictors of PH in patients with LHD.Conclusion Decreased serum levels of miR-206 are associated with increased PASP in patients with LHD,and serum miR-206 was an independent predictor of PH in patients with LHD.
【CateGory Index】: R544.1
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