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《Journal of Clinical Internal Medicine》 2019-07
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Effect of androgen on telomerase activity in aplastic anemia patients

hang Huimin;Li Xiaoyun;Zhang Shaofei;Yuan Liqian;Shi Kuizhu;Gao Xihua;Wang Rongxiao;Xie Qingqing;Zhang Yuna;Tao Chaoxin;Department of Hematology,Shijiazhuang Ping'an Hospital;  
Objective To explore the effect of androgen on telomerase activity in aplastic anemia(AA)patients and the effect of telomeres in the pathogenesis of AA.Methods A total of 30 patients who came to our hospital and the primary diagnosis was AA from January 2016 to March 2017 were enrolled as treatment group.The treatment group was divided into cyclosporine A(CsA)+androgen group and CsA group randomly with 15 cases in each group.Telomerase activity of patients before and after the treatment was detected by enzyme linked immunosorbent assay(ELISA).The telomerase activity of 15 healthy patients in our hospital was detected and compared with the treatment group.Results Baseline telomerase activity(OD value)in the treatment group(0.30 ±0.16)was significantly higher than that in the control group(0.11 ±0.06,P0.001).In CsA+androgen group,telomerase activity(OD value)decreased at 3 and 6 months after the treatment,but increased at 9 and 12 months.There was significant difference in the group before and after the treatment(P0.05),but there was no significant difference between the 2 groups(P0.05).The hematological response of CsA+androgen group was better than that in CsA group(P=0.03).Conclusion Androgen can regulate telomerase activity of AA patients.The telomerase activity increased after androgen therapy and that would repair the lost telomere length,thus the hematopoietic function of the bone marrow was restored.
【Fund】: 河北省科技计划项目(17277768D)
【CateGory Index】: R556.5
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