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《Journal of Clinaical Urology》 2002-05
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The analysis of public epitope specificity of HLA alloantibodies in highly sensitized renal transplantation recipients

YUAN Xiaopeng 1 JIANG Song 1 GAO Wei 2 JIAO Weihua 1 ( 1Department of Blood-purification & Kidney Transplantation, Taiping People's Hospital, Dongguan, Guangdong, 523905; 2Department of Blood-purification & Kidney Transplantation, Zhujiang Hosp  
Purpose:To explore the public epitope specificity analysis of human leucocyte antigen (HLA) alloantibodies in highly sensitized renal transplantation recipients. Method:The panel reactive antibody (PRA) levels of HLA alloantibodies in 24 highly sensitized recipients (HLA-class I antibody PRA50%) were monitored continually, and the antibody specificities and public epitope specificities were also analyzed. Results:Public epitope specificities of HLA alloantibodies could be identified in 87.5 %(21/24) of the patients. Analysis of public epitopes can reflect antibody spectrum more accurately than antibody specificity analysis. 16 highly sensitized recipients accepted successful kidney transplantation with compatible donor HLA antigens on the basis of antibody public epitope analysis. Conclusions:Most anti-HLA antibodies of highly sensitized recipients are directed against a small number of high frequency public epitopes of amino acid residues with high immunogenicity. Analysis of public epitopes of HLA antibodies can instruct HLA matching effectively in highly sensitized recipients.
【CateGory Index】: R699.2
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