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《Journal of Clinical Urology》 2007-04
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HIF-1α expression correlates with angiogenesis in bladder cancer

LI Fan1 YANG Weimin1 YE Zhangqun1(1Department of Urology,TongJi Hospital,TongJi Medical College,HuaZhong University of Science and Technology,Wuhan,430030,China)  
Objective:To evaluate the expression of HIF-1α in transitional cell carcinoma of the bladder(TCC)and its correlation with angiogenesis and clinical value.Methods:Immunohistochemistry,SABC,was used to detect the expression of HIF-1α,VEGF,CD34 and PCNA in 42 TCC paraffin-embedded tissue samples.The results were analyzed with the clinical data.Results:HIF-1α was obviously higher expressed in TCC than normal tissue.The significant positive associations between HIF-1α and VEGF,MVD,PCNA,and tumor recurrence were found(依次为:P0.01,P0.05,P0.01,P0.05).But no correlation was found between HIF-1α and tumor stage and grade.The angiogenesis markers were closely related to tumor grade(P0.05).In the logistic regression study,HIF-1α and PCNA were clarified as the hazard factors to tumor recurrence.Conclusions:HIF-1α plays an important role in TCC angiogenesis,and could be a new biomarker for TCC diagnosis and recurrence evaluation.It can also be expected to be a new target for anti-angiogenesis.
【CateGory Index】: R737.14
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