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《Journal of Clinical Urology》 2008-09
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Study of quercetin in inducing TRAMP-C2 cell line apoptosis in vitro

SONG Mingshan1 XING Nianzeng2(1Department of Urology, Tai’an City Central Hospital, Tai’an,Shandong,271000, China; 2Department of Urology, Beijing Chaoyang Hospital, Capital University of Medical Science)  
Objective:To investigate the effect and mechanism of quercetin in inducing the apoptosis in TRAMP-C2 cell line.Method:TRAMP-C2 cell line was treated with different concentration of quercetin in different time in vitro. The effect of inhibition of quercetin on the TRAMP-C2 cell line proliferation and inhibitive rate of cell line were tested with the MTT assay. The apoptosis rate was determined by flow cytometry, and the differential gene expression was detected using gene chip.Result:Quercetin can inhibit the proliferation and induce the apoptosis of TRAMP-C2 cell line in a dose and time-dependent manner; the gene expression of thrombospondin-1 was up-regulated.Conclusion:The results indicate that quercetin has the anti-tumor effect and induce the apoptosis of TRAMP-C2 cell line, the mechanism may be through up-regulate the gene expression of thrombospondin-1.
【Fund】: 北京市科委新星计划资助项目(H020821180190)
【CateGory Index】: R285.5;R737.25
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Chinese Journal Full-text Database 2 Hits
1 Xi-Ming Zhong,Ying Wu,Yu Fan,Department of Chemotherapy,Cancer Institute,the Affiliated People’s Hospital of Jiangsu University,Zhenjiang 212002,Jiangsu Province,China;Effects of Quercetin on invasion and midkine expression of human esophageal cancer cell[J];World Chinese Journal of Digestology;2008-22
2 YANG Bo,LI Zhi-yu*,YOU Qi-dong(Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China);The Development in the Research of Anti-tumor Mechanism of Flavonoids[J];Progress in Pharmaceutical Sciences;2008-09
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