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Changes of Plasma β Endorphin Contents during Detoxification in Heroin Addicts

Ye Xiaoming,Wang Xinhua,Li Jiale,et al Department of Anesthesiology,Chang Zheng Hospital Shanghai 200003  
Objective: To observe the changes of plasma β endorphin(β EP) contents during heroin abstinence in heroin addicts.Methods:Radioimmunoassay was used to measure the β EP content in plasma.The blood samples were obtained from 15 healthy volunteers (control group)in the morning.The blood samples were obtained from 30 heroin addicts in the morning on day 2,8 and 30 after detoxification by directly removing heroin.Results:In heroin addicts,on day 2 after detoxification,the plasma β EP content was significantly lower than that in control group ( P 0 01);on day 8 after detoxification,a significant increase was seen in comparison to that on day 2( P 0 01),but was still significantly lower than that in control group( P 0 05);on day 30 after detoxification,the plasma β EP content further increased significantly in comparison to that on day 8 ( P 0 05),and not different from that in control group.Conclusions:Heroin addiction will result in the decline of the β EP level in plasma. After herion is removed,the β EP level will gradually increase up to the normal level.The β EP level in plasma may serve as an objective indictor to estimate the clinical effect of heroin abstinence in heroin addicts.
【Fund】: 国家自然科学基金资助项目 !(批准号 3 9470 675 )
【CateGory Index】: R969.3
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