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《The Journal of Clinical Anesthesiology》 2006-03
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Effects of ketamine on LPS-induced acute lung injury in rabbits

Luo Furong,Zhong Guangling,Chen Zhiwei,et al.Department of Anesthesiology,Foshan Hospital of TCM,Foshan 528000 CHINA  
Objective To investigate the effects of ketamine on LPS-induced acute lung injury(ALI) in rabbits.Methods The LPS-induced ALI model was reproduced by two interval venous(injections) of LPS in rabbits.The rabbits were randomly divided into four groups:negative control group(group NS),positive control group(group LPS),ketamine group1(group K_1) and ketamine group 2(group K_2).Eight hours after the second LPS injection,the experiment was ended and the following indices were measured:the number of leukocytes and alveolar epithelial cells in BALF,lung water contents,lung permeability index,lung myeloperoxidase contents and lung pathologic study.(Results)(Except) the pathologic study,all the above-mentioned indices were significantly increased in group LPS compared with those in group NS(P0.01).While group NS exhibited normal pathologic results,the lungs in group LPS exhibited pathological changes of typical inflammation,including(edema,)dotted or patched surface haemorrhage,spillage fluid from cutting surface after tender squeezing.Pathological changes under microscope were constituted of pulmonary atelectasis,alveolar collapses,increased pulmonary interstitial thickness with the infiltration of numerous leukocytes,and congestion of(microvessels.) All indices and pathological changes were attenuated in group K_1 and K_2,with the latter being even more improved.Conclusion Ketamine can attenuate LPS-induced acute lung(injury) in rabbits.
【CateGory Index】: R96
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