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《The Journal of Clinical Anesthesiology》 2007-06
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Influence of intravenous propofol anaesthesia on hemorheology in rabbits

WANG Chun-yan, Liu Yu-lin, TANG Xian-ling.Department of Anesthesia,Afflitiated Hospital, Luzhou Medical College, Luzhou 646000, China  
Objective To observe the influence of intravenous propofol anaesthesia on hemorheology in rabbits.Methods Twenty rabbits were randomly divided into two groups with 10 rabbits each. The rabbits in anesthesia group were given intravenously propofol 11mg/kg for induction, and tracheotomy and endotracheal intubation for mechnical vetilation under local anesthesia were performed,Fentanyl 20μg/kg and vecuronium 0.2mg/kg were used intravenously for the maintenance of anesthesia. The rabbits in control group were infused intravenously with equal volume of normal saline instead of anesthetics. Blood samples were drawn before and at 10min after drug administration for the measuremens of hemorheological parameters.Results In observing group, the whole blood viscosities (ηb, a shear rate of 200s-1,30s-1 and 3s-1 at 37℃) were droped slightly,plasma viscosity(ηp) was decreased sharply (P0.01),while erythrocyte aggregation index(EAI) and rigidity index(ERI) were increased after anesthesia compared with those before anesthesia.In control group there was a markedly reduction of all the parameters except erythrocyte deformability index(EDI).Conclusion Intravenous propofol anaesthesia has adverse effects on erythrocyte rheology in rabbits.
【Fund】: 四川省教委重点科研基金资助(编号:0236/440)
【CateGory Index】: R614
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【Citations】
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1 Zhang Yan, Qian Hongdi, Shen Zhiyun, et al. Department of Anesthesiology, Wuxi Fourth People's Hospital. Wuxi 214062 CHINA;Effect of different methods of analgesia on hemorheology and troponin T of the myocardium in old patients with thoracic surgery[J];The Journal of Clinical Anaesthesiology;2004-08
【Co-citations】
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1 LI Yong,XIA Cui-ying,L Ming-an (Jiangsu Kanion Pharmaceutical Company Limited,Jiangsu Lianyungang 220001,China);Effect of Wei-wei Decoction on the Indexes of Blood Rheology of Rats with Qi-deficiency-blood-stasis Syndrome[J];Journal of Anhui Traditional Chinese Medical College;2005-01
2 LIANG Hua, YANG Cheng-Xiang, LI Heng, LIU Hong-Zhen, WANG Han-Bing Department of Anesthesiology, Affiliated Foshan Hospital, Sun Yat-sen University, Foshan, Guangdong, 528000, P. R. China;Effects of Preoperative Acute Hypervolemic Hemodilution on Hypercoagulability of Patients with Colon Cancer[J];Chinese Journal of Cancer;2006-10
3 GAO Xiang,FENG Yan xian,SUN Bao ling,YANG Hai hong (Department of Cardiovascular Diseases,Bengbu Third People's Hospital,Anhui 233000 ,China);Use of low molecular-weight heparin calcium prior to thrombolytic therapy for acute myocardial infarction[J];Journal of Bengbu Medicinae College;2001-06
4 SI Chun-qiang(Department of Vascular Surgery,Yijishan Hospital,Wannan Medical College,Wuhu 241001,China);Apoptosis of endothelial cells after deep venous thrombosis in rabbits[J];Journal of Bengbu Medical College;2007-05
5 Wang Dong,Wang Yiping Anhui College of TCM,Hefei(230038);P-selection and Kidney Disease[J];Journal of Zhejiang University of Traditional Chinese Medicine;2008-04
6 Zhao Ying,Jiang Shufang,Yuan Min (Yishui Central Hospital,276400);EFFECT OF PASSIVE AND INITIATIVE MOVEMENT OF LOWER EXTREMITIES ON BLOODFLOW VELOCITY IN THE FEMORAL VEIN OF OLD PATIENTS AFTER PROSTATECTOMY[J];Journal of Binzhou Medical College;2004-01
7 QIAN Sheng-wei GAO Bao-shan JIN Dian-shi CHANG Qing-yong ZHANG Ji-zhi HUANG Kun QU Kai.Department of Neurosurgery,Zhongshan Hospital,Dalian University,Dalian 116001,China;Venous thromboembolism in neurosurgery[J];Chinese Journal of Neuromedicine;2006-07
8 YU Hai-Ying,WANG Zong-Ren,MA Jing,WEI Li-Qiang Department of Traditional Chinese Medicine,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Effects of QiDanTongMai Tablet on anti-thrombosis function of endothelial cells[J];Journal of The Fourth Military Medical University;2005-10
9 LIU Bao-ying 1 , ZHONG Mei 1 , YU Yan-hong 1 , LI Jing-shan 1 , ZHENG Lei 2 , WANG Qian 21 Department of Obstetrics and Gynecology, 2 Department of Clinical Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Assessment of variables relative to prethrombotic state after operation in patients with gyneco- logical malignancies[J];Journal of First Military Medical University;2003-01
10 WANG) Shaobo~(1)),SHI Bingyin~(2)),WANG Yangwei~(1)),WU Guifu~(1)).1)Department of Endocrinology,Shanxi Provincial People's Hospital,Xi'an 710068,Shanxi;2)Department of Endocrinology,the First Hospital of Xi'an Jiao Tong University,Xi'an 710061,Shanxi;The relationship between changes of plasma fibrinolysis and coagulation parameters and type 2 diabetic(microangiopathy[J];Clinical Medicine;2006-07
【Secondary Citations】
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1 Cheng Qiao, Yang Baxian Department of Anesthesiology, First Affiliated Hospital, Shan Xi Medical University, Tai Yuan;The Effects of Different Anesthetic Techniques on Haemorheology in Patients Undergoing Total Hip Replacement[J];THE JOURNAL OF CLINICAL ANESTHESILOLGY;1999-01
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