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《The Journal of Clinical Anesthesiology》 2008-08
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Protective effect of ulinastatin on the lungs in patients with pulmonary hypertension during open heart surgery

XUE Qing-hua,CHANG Ke-qin,CHENG Wei-ping,et al.Department of Anesthesiology,Cardiovascular Institute and Fuwai Hospital, CAMS & PUMC, Beijing 100037, China  
Objective To study the protective effect of ulinastatin (UST)on lung function in the patients with pulmonary hypertension(PH) during open heart surgery. Methods Thirty ASA class Ⅱ or Ⅲ patients scheduled for selective cardiac valve replacement were randomly allocated into two groups with 15 cases each.Group U was given UST 0.6 kIU/kg before cleaving the breastbone and release of the aortic cross-clamping, respectively, and group C received saline as the control.Before operatioin (T1) and at 30 min after release of the aortic cross-clamping (after the effects of heparin being neutralized by protamine, T2),bronchoalveolar lavage fluid(BALF) was collected from the right middle lobe of the lung for the measurement of interloukin 8 (IL-8) concentration with enzyme-linked immunosorbent assay. At the same time points,blood samples were collected from radial artery for blood gas analysis in order to calculate arterial-alveolar difference of oxygen tension (PA-aDO2) and respiratory index(RI). Results The concentration of IL-8 in BALF, PA-aDO2 and RI were all increased significantly at T2 compared with those at T1 in group C (P0.05), which were remarkably lower in group U than those in group C at T2 (P0.05). Conclusion UST protects PH patients undergoing open heart surgery under cardiopulmonary bypass(CPB) against acute lung injury induced by CPB through the inhibition of the enhanced local expression of leukocyte.
【CateGory Index】: R614;R654.2
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