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《The Journal of Clinical Anesthesiology》 2010-09
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Expressions of CGRP mRNA and related protein in trigeminal ganglia of trigeminal neuralgia rat

WANG Yan-xiu,TIAN Yu-ke,MA Gui-fen,et al. Department of Anesthesiology,Tongji Hospital of Tongji Medical College,Huazhong Univesity of Science and Technology,Wuhan 430030,China  
Objective To explore the effect of calcitonin gene-related peptide (CGRP) in mechanisms of trigeminal neuralgia. Methods Forty Wistar male rats were randomly divided into experimental group(A) and control group(C). An unilateral chronic constriction injury (CCI) was produced on the infraorbital nerve (ION),one of the trigeminal nerves,in group A. The pain-related behaviour was observed. The section of trigeminal ganglia underwent immunohistological and situ hybridization study. Light microscope and microscopic photo analytic software were employed to detect the expressions of CGRP and CGRP mRNA in frozen section of TGs. Results Pain threshold decreased and the expressions of CGRP and CGRP mRNA were enhanced from 2 to 8 weeks after operation in group A compared with group C(P0.01) and there was no significant difference on the 12th week between two groups.Conclusion CGRP and CGRP mRNA may be involved in the mechanism of trigeminal neuralgia.
【Fund】: 泰安市科技局资助项目(编号:2003-52)
【CateGory Index】: R745.11
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