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《Journal of Clinical Anesthesiology》 2013-03
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Effect of dexmedetomidine on inflammatory response and oxidative stress during one-lung ventilation

ZHANG Wei,ZHANG Jia-qiang,MENG Fan-min.Department of Anesthesiology,Henan Provincal People's Hospital,Zhengzhou 450003,China  
Objective To observe the effect of dexmedetomidine on inflammatory response and oxidative stress during one-lung ventilation.Methods Forty patients,ASA Ⅰ or Ⅱ,aged 45-64,with body mass index lower than 30 kg/m2,were randomly divided into two groups(n=20): dexmedetomidine group (group D) and control group (group C). Dexmedetomidine 1 μg/kg were infused 10 min after tracheal intubation,followed by continous infusion of dexmedetomidine at rate of 0.5 μg·kg-1·h-1.Normal saline with equal volume were administrated in group C. Venous blood samples were obtained at three time points:the beginning of OLV,60 min after OLV and the end of operation. MDA,SOD,TNF-α and IL-6 were detected. Results Compared to T0,the activity of SOD were decreased, the plasma concentration of MDA, TNF-α and IL-6 were increased in both groups at T2 (P0.05); Compared to group C, the activity of SOD were increased in group D,the plasma concentration of MDA, TNF-α and IL-6 were decreased at T2(P0.05).Conclusion Dexmedetomidine could inhibit inflammatory response and oxidative stress during one-lung ventilation in patients udergoing elective resection of esophageal carcinoma,it has positive effect on the lung protection in clinical process.
【Fund】: 河南省科技厅项目(122300410068)
【CateGory Index】: R614
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