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《Journal of Clinical Neurology》 2000-05
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Study on the establishment of an animal model of experimental myositis

Zhao Hongdong, Chen Zushun, Shen Mingjiu. (Department of Neurology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210006)  
Objective To study the way on the establishment of an animal model of experimental myositis. Methods An animal model of experimental myositis was produced in guinea-pigs by rabbit skeletal muscle homogenates with Freund's complete adjuvant(FCA). The observation was made on serum muscle enzymes,Electromyography(EMG) and muscle biopsy to find out their features as compared with human polymyositis(PM). Results There were similarities in serum muscle enzymes,EMG and muscle biopsy between experimental myositis and human polymyositis. Conclusion The result suggested an animal model of experimental myositis might serve as an important means for studying polymyositis in human, and offered the theory basis for its etiopathology and therapy.
【CateGory Index】: R-332
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