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《Chinese Journal of Clinical Neurosciences》 1998-03
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Effects of Astragaloside I on Cerebral GSH-px and MDA Contents Following Middle Cerebral Artery Occlusion in Mice

Luo Yu-Min, Qin Zhen Institute of Neurology, Shanghai Medical University, Shanghai 200040  
Free radicals formation and lipid peroxidation were thought to potentiate ischemic brain cell injury. In the present study DTNB method and a-thiobarbituric acid method were applied to measure the activity of GSH-px and the concentration of MDA respectively following MCAO in mice. The results showed that there was no significant difference in cerebral GSHpx activity between ischemic group and sham operated group, while MDA concentration markedly increased in ischemic group compared with the sham operated group (P0. 01). Injection of astragaloside I intraperitoneally at 1 hour before the MCAO mildly enhanced GSH-px activity, but markedly decreased MDA concentration (P0. 01). These facts suggest that astragaloside I might protect the cerebral tissue against the free radical damage in ischemia.
【CateGory Index】: R277.7
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