Progressive Atrophy of the Thalamus Following Middle Cerebral Artery Occlusion in Rats
ZHANG Shi-Ming,ZHOU Dai (Department of Neurosurgery, First Hospital Affiliated to Suzhou Medical College, Suzhou 215006)
Aim: To investigate the change of thalamus after long-term permanent middle cerebral artery occlusion (MCAO). Methods: 35 rats were divided into 7 groups in average, the middle cerebral artery was occluded with Tamura method except normal and sham groups. All rat slices were stained by the rat brain monoclonal antibody MAP-2 and the areas of the right and left thalamus were measured by computer digitizer. Results: The ration of the ipsilateral and contralateral tha- lamus was 0.99±0. 01 at normal group, 1.0±0.01 at sham group, 0.87±0. 03 at MCAO 2-week group, 0.78±0.03 at MCAO 1-month group, 0.71±0.04 at 3-month group, 0.61±0. 05 at 6-month group. There was a significant difference be- tween the sham group and MCAO groups (P0.001). Conclusion: It is indicated that retrograde degeneration is thought to play an important role in thalamus atrophy.