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《Chinese Journal of Clinical Neurosciences》 2001-01
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Effects of Dieldrin on the Proliferation of PC12 Cell and the Expression of Tyrosine Hydroxylase mRNA

PENG Xiang Min,REN Hui Min,JIANG Yu Ping  Institute of Neurology, Fudan University, Shanghai 200040  
Aim:To evaluate the possible pathogenesis of dieldrin by measuring the PC12 cell survival and the expression of tyrosine hydroxylase mRNA (THmRNA) after incubation with dieldrin for 24h.Methods:PC12 cells were selected in this study. MPP + was used as a positive control. After 24h of growth, various concentrations of MPP + and dieldrin (10 -4 ~1 mmol·L -1 ) were added to the growth medium for 24h. PC12 cell survival was examined and the expression of THmRNA was measured by using RT PCR. Results:(1) Both MPP + and dieldrin had toxic effects on PC12 cell. The PC12 cell survival significantly decreased to 45 % of the control after incubation with 1 mmol·L -1 MPP + for 24h. However, MPP + had no effect on cell survival when its concentration was lower than 1 mmol·L -1 . The PC12 cell survival significantly decreased to 30 % ( P 0 01) of the control after incubation with 0.1 mmol·L -1 dieldrin for 24 h. Morever, after treating with 1 mmol·L -1 dieldrin for 24h, the PC12 cells were totally dead. (2) Both MPP + and dieldrin had toxic effects on the expression of THmRNA. When PC12 cells were incubated with 0.1 mmol·L -1 MMP + and dieldrin for 24 h, the expressions of THmRNA were decreased to 69.3% ( P 0 05) and 61.7% ( P 0 01) of the control,respectively. Conclusion:Dieldrin, which has stronger toxic effects on PC12 cell survival and the expression of THmRNA than MPP +,may be a potential etiological agent for parkinsonism.
【Fund】: 国家教委博士点科学研究基金课题 (9831 )
【CateGory Index】: R742.5
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