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Decrease of Dopamine Transporter in Striatum of Parkinsonian Mice Induced by Paraquat

REN Jin Peng,REN Hui Min,JIANG Yu Ping Department of Neurology,Huashan Hospital, Fudan University, Shanghai 200040,China  
Aim:To explore whether the dopamine transporter (DAT) was involved in pathogenic mechanism of Parkinsonian mice induced by Paraquat.Methods:The methods of immuno histochemistry and in situ hybridization were applied respectively to observe the changes of DAT in striatum and the expression of DAT mRNA in substantia nigra of Parkinsonian mice induced by Paraquat taken orally.Results:Mice treated by Paraquat(10 mg·kg -1 )taken orally for two months displayed a marked hypoactive behavior. Levels of DAT in striatum of mice were decreased by 42%( P 0 01),and the expression of DAT mRNA were also decreased by 37.2% compared to the mice treated by saline taken orally( P 0 01).Conclusion:Paraquat could induce mice to appear a series of the behaviors that were similar to Parkinson′s disease. DAT could be involved in the pathogenic mechanism of Parkinson′s disease. DAT could be involved in the pathogenic mechanism of Parkinson′s disease,because of the decreased levels of both the protein and mRNA expression.
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