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《Chinese Journal of Clinical Neurosciences》 2002-03
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Evaluation of the Value for ~(99m)Tc-TRODAT-1 SPECT Imaging of Dopamine Transporter in Diagnosis of Parkinson's Disease

ZHAO Yong Fei, JIANG Yu Ping, CHEN Zhen Ping , et al Department of Neurology,Huashan Hospital, Fudan University, 200040; State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, 214063,China  
Aim:To evaluate the value of 99m Tc TRODAT 1 SPECT DAT imaging in the early diagnosing of Parkinson's disease (PD).Methods:Ten patients (7 early PD and 3 advanced PD) and 2 healthy controls were studied with 99m Tc TRODAT 1 SPECT DAT imaging. Striatum specific uptake of 99m Tc TRODAT 1 was calculated according to the ratios of DAT uptake in striatum/frontal cortex (ST/FC) and striatum/occipital cortex(ST/OC). Results:In the early Parkinson's disease group, the ratios of ST/FC(1.106±0.041) and ST/OC (1.123±0.045) was significantly lower (both P 0 01) in contralateral than in ipsilateral striatum to the clinically symptomatic side. There was significant decrease ( P 0 01) of the ratios of ST/FC and ST/OC of ipsilateral striatum to the clinically symptomatic side in early patients compared to the controls, but significant increase to the advanced patients. Conclusion: 99m Tc TRODAT 1 SPECT brain imaging may help to confirm the diagnosis of PD at the early stage.
【CateGory Index】: R817.4
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