Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Neurosciences》 2002-03
Add to Favorite Get Latest Update

Evaluation of the Value for ~(99m)Tc-TRODAT-1 SPECT Imaging of Dopamine Transporter in Diagnosis of Parkinson's Disease

ZHAO Yong Fei, JIANG Yu Ping, CHEN Zhen Ping , et al Department of Neurology,Huashan Hospital, Fudan University, 200040; State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, 214063,China  
Aim:To evaluate the value of 99m Tc TRODAT 1 SPECT DAT imaging in the early diagnosing of Parkinson's disease (PD).Methods:Ten patients (7 early PD and 3 advanced PD) and 2 healthy controls were studied with 99m Tc TRODAT 1 SPECT DAT imaging. Striatum specific uptake of 99m Tc TRODAT 1 was calculated according to the ratios of DAT uptake in striatum/frontal cortex (ST/FC) and striatum/occipital cortex(ST/OC). Results:In the early Parkinson's disease group, the ratios of ST/FC(1.106±0.041) and ST/OC (1.123±0.045) was significantly lower (both P 0 01) in contralateral than in ipsilateral striatum to the clinically symptomatic side. There was significant decrease ( P 0 01) of the ratios of ST/FC and ST/OC of ipsilateral striatum to the clinically symptomatic side in early patients compared to the controls, but significant increase to the advanced patients. Conclusion: 99m Tc TRODAT 1 SPECT brain imaging may help to confirm the diagnosis of PD at the early stage.
【CateGory Index】: R817.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 TANG Jie,CHEN Zheng-ping,LI Xiao-min,WANG Song-pei,LIU Chun-yi,QIN Xiao-feng,ZHOU Xing-qin(Key Laboratory of Nuclear Medicine,Sponsored by the Ministry of Health,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China);RPHPLC Determination of nor-CClT the Precursor in Preparation of the Labelled Compound ~(18)F-FECNT[J];Physical Testing and Chemical Analysis(Part B:Chemical Analysis);2010-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Li~1,TANG Yong~(2,3),YU Shu-guang~3(1.Clinical Department,Medical College,Tibet University,850000;2.Institute of Biomedical Engineering,West China Center of Medical Science,Sichuan University,610041;(3.Chengdu University of Traditional Chinese Medicine,610075);Incrased Expression of Dopamine Transporter in Parkinson's Disease Mice Substantia Nigra by Electroacupuncture Therapy[J];Journal of Chengdu University of Traditional Chinese Medicine;2006-03
2 ;Brain Receptor Imaging[J];China Comtemporary Medicine;2001-09
3 ;The Imaging of Dopamine Transporter in Brain--αNew Method for Diagnosis of Parkinson's Disease[J];China Comtemporary Medicine;2001-12
4 XU Long-bao, CHEN Zhuo-you, YANG Yan-wen , LIU Jian-wen, WAN Ren-ming, ZHAO Jun, HUANG Shu-xin, QIAN Chuan-zhong (Nanjing Medical University Attached Changzhou Second People's Hospital,Changzhou Jiangsu 213003);The effective method to investigate the severity of Parkinson disease:DAT SPECT imaging with ~(99m)Tc-TRODAT-1[J];Journal of Gannan Medical University;2008-03
5 SUN Wen shan (Department of Nuclear Medicine, Shanghai Ruijin hospital, Shanghai Second Medical University, Shanghai 200025,China);Several new imaging agents for central dopamine transporter[J];Foreign Medical Science.radiomedicine and Nuclear Medicine;2000-02
6 BIAN Yan zhu 1, LIU Huai jun 1, FENG Jue 2, TIAN Rui zhen 3, HA Zhi yuan 3 (1.Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China; 2.Department of Nuclear Medicine, Hebei Provincial People's Ho;CLINICAL VALUE OF ~(99) Tc~m-TRODAT-1 DOPAMINE TRANSPORTER SPECT IMAGING IN EARLY DIAGNOSIS OF PARKINSON'S DISEASE[J];Journal of Hebei Medical University;2002-05
7 HU Ping1; ZHOU Zhifa2; LIN Zhanjiang2; LI Guangxian2; HU Xiaoke3 1 (The First Affiliated HOspital, Sun Yat - sen University of Medical sciences, Guangzhou 510080) 2 (Guangzhou Analytical Measurement Center, Guangdong Measurement Analytical Institute, Guangzhou) 3 (Sun Yat - sen University of Medical Sciences, Guangzhou 510080);~(125)I-β-CIT Biodistribution Study in animals[J];Nuclear Techniques;2000-05
8 JIANG Zhong WANG Feng LIU Zengli TANG Jun WU Jinchang (Department of Nuclear Medicine, Second Hospital Affiliated to Suzhou University, Nuclear Medicine Institute of Suzhou University, Suzhou 215004);Calculation of the internal radiation absorbed dose of ~(99m)Tc-TRODAT-1[J];Nuclear Techniques;2002-11
9 XIA Jiaoyun WANG Yongxian YU Junfeng YIN Duanzhi (Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800);Biolabeling and application of the fac-[Μ(CO)_3]~+(Μ=~(188/186)Re,~(99)Tc~m) compounds[J];Nuclear Techniques;2004-09
10 LI Xiaomin1 CHEN Zhengping1* WANG Songpei1 TANG Jie1 LIN Yansong2 ZHU Zhaohui2 FANG Ping1 (1 Jiangsu Institute of Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health , Wuxi 214063, China; 2 PET Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China);The preclinical pharmacological study of dopamine transporter imaging agent ~(18)F-FP-β-CIT[J];核技术(英文版);2007-04
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 KAI Xiao ming (The Chem.Dept.of Anqing Normal College,Anqing 246011,China);A Accuracy investigation of second derivative method to determine an end point of weak acid-Bases potentiometric titration[J];Journal of Anqing Teachers College(Natural Science Edition);2001-02
2 DENG Hao yu (Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China);Application of rCBF imaging in PD, AD and OPCA[J];Bulletin of Hunan Medical University;2002-03
3 FU Chun mei , LIU San kang,LI Zhang wan,XIONG Chun yan West China School of Pharmacy, Sichuan University , Chengdu 610041,China;Determination of edaravone[J];West China Journal of Pharmaceutical Sciences;2003-03
4 DINCZheng-Tong; REN Hui-Min; JIANG Yu-Ping; CAI Zhen-Ling; ZHU Qiu-YuDepartment of Neurology, Huashan Hospital, Medical Center of Fudan University,Shanghai 200040;The Influence of Acute Intoxication of Dieldrin on the Level of Dopamine in Striatum of Mice[J];Chinese Journal of Clinical Neurosciences;2000-04
5 PENG Xiang Min,REN Hui Min,JIANG Yu Ping  Institute of Neurology, Fudan University, Shanghai 200040;Effects of Dieldrin on the Proliferation of PC12 Cell and the Expression of Tyrosine Hydroxylase mRNA[J];Chinese Journal of Clinical Neurosciences;2001-01
6 REN Jin Peng,REN Hui Min,JIANG Yu Ping Department of Neurology,Huashan Hospital, Fudan University, Shanghai 200040,China;Decrease of Dopamine Transporter in Striatum of Parkinsonian Mice Induced by Paraquat[J];Chinese Journal of Clinical Neurosciences;2002-01
7 DING Zheng Tong, REN Hui Min,JIANG Yu Ping , et al. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040,China;Adult C57b1 Mice Could Develop Symptoms Similar to Parkinson′s Disease after the Exposure to Paraquat[J];Chinese Journal of Clinical Neurosciences;2002-03
8 YANG Shi-gang(Dept. of Chem. Engineering, Shanghai Institute of Applied Technology, Shanghai 200235, China);NON-AQUEOUS TITRATION OF CONTENT OF 1-PHENYL-3-HYDROXY-1, 2,4-TRIAZOLE[J];Physical Testing and Chemical Analysis Part B Chemical Analysis;2004-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved